Changes in the default mode network in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users

被引：6
|
作者：
Hu, Wenfu [1 ]
Fu, Xiangming [1 ,2 ]
Oian, Ruobing [2 ]
Wei, Xiangpin [2 ]
Ji, Xuebing [3 ]
Niu, Chaoshi [2 ]
机构：
[1] Anhui Med Univ, Dept Neurosurg, Prov Hosp, Hefei 230001, Anhui, Peoples R China
[2] Anhui Prov Inst Stereotact Neurosurg, Dept Neurosurg, Hefei 230001, Anhui, Peoples R China
[3] Anhui Med Univ, Dept MRI, Prov Hosp, Hefei 230001, Anhui, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 18期
基金：
中国国家自然科学基金;
关键词：
heroin user; independent component analysis; functional MRI; resting state; default mode network; neural regeneration; HUMAN BRAIN; WORKING-MEMORY; RESTING-STATE; ADDICTION; MRI; DYSFUNCTION; DISEASE;
D O I：
10.3969/j.issn.1673-5374.2012.18.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The default mode network is associated with senior cognitive functions in humans. In this study, we performed independent component analysis of blood oxygenation signals from 14 heroin users and 13 matched normal controls in the resting state through functional MRI scans. Results showed that the default mode network was significantly activated in the prefrontal lobe, posterior cingulated cortex and hippocampus of heroin users, and an enhanced activation signal was observed in the right inferior parietal lobule (P < 0.05, corrected for false discovery rate). Experimental findings indicate that the default mode network is altered in heroin users.
引用
收藏
页码：1386 / 1391
页数：6
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