Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score

被引：91
|
作者：
Lam, John S.
Seligson, David B.
Yu, Hong
Li, Ai
Eeva, Mervi
Pantuck, Allan J.
Zeng, Gang
Horvath, Steve
Belldegrun, Arie S.
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biostat, Los Angeles, CA USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA USA
来源：
BJU INTERNATIONAL | 2006年 / 98卷 / 02期
关键词：
flap endonuclease 1; Gleason grade; prostate cancer; tissue microarray; tumour markers; EUKARYOTIC DNA-REPLICATION; CELL NUCLEAR ANTIGEN; GENE FEN1; EXPRESSION; IDENTIFICATION; OPTIMIZATION; MITOXANTRONE; EXONUCLEASE; MICROARRAYS; PREDNISONE;
D O I：
10.1111/j.1464-410X.2006.06224.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
To investigate the expression and potential clinical usefulness of structure-specific flap endonuclease 1 (FEN-1) in human primary prostate cancer using tissue microarray technology, as FEN-1 was recently identified to be overexpressed in CL1.1, the most aggressive clone generated from the hormone-refractory prostate cancer cell line CL1.
引用
收藏
页码：445 / 451
页数：7
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