An Improved and Scalable Process for Celecoxib: A Selective Cyclooxygenase-2 Inhibitor

被引：24
|
作者：
Reddy, Anumula Raghupathi [2 ]
Sampath, Alla [2 ]
Goverdhan, Gilla [2 ]
Yakambaram, Boja [2 ]
Mukkanti, Kagga [1 ,2 ]
Reddy, Padi Pratap [2 ]
机构：
[1] JNT Univ, Inst Sci & Technol, Ctr Environm Sci, Hyderabad 500072, Andhra Pradesh, India
[2] Dr Reddys Labs Ltd, Dept Res & Dev, Integrated Prod Dev, R R Dist 500072, AP, India
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2009年 / 13卷 / 01期
关键词：
COX-2; INHIBITORS; DERIVATIVES; PYRAZOLES; SC-58635;
D O I：
10.1021/op800158w
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An improved, scalable and commercially viable process is developed for an active pharmaceutical ingredient, celecoxib.
引用
收藏
页码：98 / 101
页数：4
相关论文
共 50 条
  • [31] The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARγ.: Influence of albumin
    López-Parra, M
    Clària, J
    Titos, E
    Planagumà, A
    Párrizas, M
    Masferrer, JL
    Jiménez, W
    Arroyo, V
    Rivera, F
    Rodés, J
    JOURNAL OF HEPATOLOGY, 2005, 42 (01) : 75 - 81
  • [32] The selective cyclooxygenase-2 inhibitor celecoxib reduces bone resorption, but not bone formation, in ovariectomized mice in vivo
    Kasukawa, Yuji
    Miyakoshi, Naohisa
    Srivastava, Apurva K.
    Nozaka, Koji
    Maekawa, Shigeto
    Baylink, David J.
    Mohan, Subburaman
    Itoi, Eiji
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 211 (03): : 275 - 283
  • [33] Induction of cell cycle arrest and apoptosis in colon cancer cells by the selective cyclooxygenase-2 inhibitor celecoxib
    Grösch, S
    Niederberger, E
    Tegeder, I
    Geisslinger, G
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2001, 363 (04) : R127 - R127
  • [34] Cardiovascular thrombotic events in arthritis trials of the cyclooxygenase-2 inhibitor celecoxib
    White, WB
    Faich, G
    Borer, JS
    Makuch, RW
    CIRCULATION, 2002, 106 (19) : 721 - 721
  • [35] Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor ameliorates perphenazine-induced catatonia in rats
    Gupta, A.
    Dhir, A.
    Kumar, A.
    Kulkarni, S. K.
    INDIAN JOURNAL OF PHARMACOLOGY, 2008, 40 : 138 - 138
  • [36] Cardiovascular thrombotic events in arthritis trials of the cyclooxygenase-2 inhibitor celecoxib
    White, WB
    Faich, G
    Borer, JS
    Makuch, RW
    AMERICAN JOURNAL OF CARDIOLOGY, 2003, 92 (04): : 411 - 418
  • [37] Celecoxib, a Selective Cyclooxygenase-2 Inhibitor, Improves a Bone Resorption Marker in Postmenopausal Women with Rheumatoid Arthritis
    Tsuji, Shigeyoshi
    Tomita, Tetsuya
    Iwai, Takao
    Nakase, Takanobu
    Hamada, Masayuki
    Kawai, Hideo
    Yoshikawa, Hideki
    ARTHRITIS AND RHEUMATISM, 2011, 63 (10): : S856 - S856
  • [38] Cardiovascular thrombotic events are not increased on the cyclooxygenase-2 inhibitor celecoxib.
    White, WB
    Faich, G
    Borer, JS
    Makuch, R
    ARTHRITIS AND RHEUMATISM, 2002, 46 (09): : S211 - S211
  • [39] Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: A randomized controlled trial
    Bensen, WG
    Fiechtner, JJ
    McMillen, JI
    Zhao, WW
    Yu, SS
    Woods, EM
    Hubbard, RC
    Isakson, PC
    Verburg, KM
    Geis, GS
    MAYO CLINIC PROCEEDINGS, 1999, 74 (11) : 1095 - 1105
  • [40] Effects of Celecoxib (A Cyclooxygenase-2 Inhibitor) on Benign Prostatic Hyperplasia in Rat
    Sarbishegi, Maryam
    Khajavi, Ozra
    Manesh, Mohammad Rigi
    JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE, 2018, 6 (03): : 60 - 68
12345