An oxathiaphospholane approach to one-pot phosphorothioylation of isoprenoid alcohols

被引：6
|
作者：
Zmudzka, K
Nawrot, B
Chojnacki, T
Stec, WJ
机构：
[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Bioorgan Chem, PL-90363 Lodz, Poland
[2] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 09期
关键词：
D O I：
10.1021/ol049771o
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Allyl, isopentenyl, geranyl, citronellyl, farnesyl, and phytyl alcohols were transformed in good yield (>60%) into their phosphorothioates via a DBU-assisted 1,3,2-oxathiaphospholane ring-opening condensation with 2-(2-cyanoethoxy)-2-thiono-1,3,2-oxathiaphospholane, a reagent that is stable and easy to handle, followed by subsequent removal of the 2-cyanoethyl group from the intermediate phosphorothioate diester under basic conditions.
引用
收藏
页码：1385 / 1387
页数：3
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