The oxidation of 3-hydroxy-3-methyl-Δ4-steroids by chromium trioxide

被引：0
|
作者：
Uyanik, C
Hanson, JR [1 ]
Hitchcock, PB
机构：
[1] Univ Sussex, Dept Chem, Brighton BN1 9QJ, E Sussex, England
[2] Kocaeli Univ, Dept Chem, TR-41300 Izmit, Kocaeli, Turkey
来源：
JOURNAL OF CHEMICAL RESEARCH-S | 2003年 / 12期
关键词：
tertiary allylic alcohols; 3-hydroxy-3-methyl-Delta(4)-steroids; chromium trioxide; oxidation; epoxidation;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Oxidation of the allylic tertiary alcohols of 3-hydroxy-3-methyl-Delta(4)-steroids by chromium trioxide in sulfuric acid leads to C-C bond fission together with the formation of a 3-methylestra-1,3,5(10)-triene from a 19-nor steroid and a 3beta,4beta-epoxy-5beta-hydroxy compound from an androstane; the structure of the hydroxy-epoxide was established by X-ray crystallography.
引用
收藏
页码：795 / 797
页数：3
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