Biosynthesis and Stability of Coiled-Coil Peptides Containing (2S,4R)-5,5,5-Trifluoroleucine and (2S,4S)-5,5,5-Trifluoroleucine

被引：50

作者：

Montclare, Jin Kim ^{[2
]}

Son, Soojin ^{[1
]}

Clark, Ginevra A. ^{[3
]}

Kumar, Krishna ^{[3
,4
]}

Tirrell, David A. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[2] Polytech Univ, Suny Downstate Med Ctr, Dept Biochem, Dept Chem & Biol Sci, Brooklyn, NY 11203 USA

[3] Tufts Univ, Dept Chem, Medford, MA 02155 USA

[4] Tufts Univ New England Med Ctr, Ctr Canc, Boston, MA 02110 USA

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 01期

基金：

美国国家科学基金会;

关键词：

biosynthesis; noncanonical amino acids; protein engineering; stereochemical control; thermostability; 4-ALPHA-HELIX BUNDLE PROTEIN; NONCANONICAL AMINO-ACIDS; TRANSFER-RNA SYNTHETASE; ESCHERICHIA-COLI; GENETIC-CODE; ISOLEUCINE; DESIGN; HEXAFLUOROLEUCINE; STABILIZATION; FLUORINE;

D O I：

10.1002/cbic.200800164

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：84 / 86

页数：3

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