Circadian changes in pharmacokinetics of cyclosporin in healthy volunteers.

被引：0

作者：

Choi, JS ^{[1
]}

Park, HJ ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Dong Gu, Kwangju 501759, South Korea

来源：

RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY | 1999年 / 103卷 / 01期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circadian changes in the pharmacokinetics of cyclosporin were evaluated after oral administration of the drug, 300 mg, at 09:00 and 20:00 to twelve healthy male subjects. At 09:00, the blood concentrations of cyclosporin were higher, the area under the blood concentration-time curve from time 0 to time infinity was significantly greater (9.70 versus 8.42 mu g.hr/ml), and the renal clearance was significantly slower (1.14 versus 1.48 ml/min) than those at 22:00. The terminal half-life, peak concentration, and time to reach peak concentration were not significantly different between two groups.

引用

页码：109 / 112

页数：4

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