Kinetic resolution of secondary alcohols mediated by rabbit gastric lipase

被引：13
|
作者：
Legros, JY
Toffano, M
Drayton, SK
Rivard, M
Fiaud, JC
机构：
[1] Lab. de Synthese Asymetrique A., Inst. de Chim. Moleculaire d'Orsay, Université de Paris-Sud
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 11期
关键词：
D O I：
10.1016/S0040-4039(97)00242-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Secondary benzylic alcohols were kinetically resolved by rabbit gastric lipase-mediated acylation with isopropenyl acetate. Among all the substrates tested, a high enantioselectivity was observed only for l-[2-(6-methoxy)naphthyl]ethanol 3a (E>500). Allylic alcohols 14a and 15a were also efficiently, resolved (E = 26 and 51 respectively). (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：1915 / 1918
页数：4
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