Pathomorphology of drug-induced hepatopathy

被引：0
|
作者：
Madej, JA [1 ]
机构：
[1] Fizjopatol & Weterynarii Sadowej Wydzialu Medycyn, Katedra Anat Patologicznej, PL-50375 Wroclaw, Poland
来源：
MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE | 2002年 / 58卷 / 03期
关键词：
drug-induced hepatic injury; necrosis; lipid degeneration; inflammation; cholestasis; cirrhosis;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Interaction between drugs and liver includes three groups of problems: 1) the metabolism of drugs in the liver; 2) damage of the liver by drugs (drug-induced hepatopathy); and 3) the influence of existing pathological liver changes on the metabolism of the drugs. The pathomorphological changes may be caused by drug-induced hepatic injury and are divided into cytotoxic changes (necrosis, lipid degeneration, inflammation), cholestatic changes (cholestasis, billiary cirrhosis) and cytotoxiccholestatic changes. These changes could be a cause of acute or chronic liver failure.
引用
收藏
页码：163 / 168
页数：6
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