Up-regulation of Hrk, a regulator of cell death, in retinal ganglion cells of axotomized rat retina

被引：28
|
作者：
Wakabayashi, T
Kosaka, J
Hommura, S
机构：
[1] Univ Tsukuba, Inst Clin Med, Dept Ophthalmol, Tsukuba, Ibaraki 3058575, Japan
[2] Okayama Univ, Sch Med, Dept Anat, Okayama 7008558, Japan
来源：
NEUROSCIENCE LETTERS | 2002年 / 318卷 / 02期
关键词：
apoptosis; Axotomy; BH3-only protein; Hrk; in situ hybridization; retinal ganglion cells; reverse transcription-polymerase chain reaction;
D O I：
10.1016/S0304-3940(01)02487-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Hrk, a regulator of cell death, belongs to the family of pro-apoptotic BH3-only proteins and is known to induce apoptosis in nerve tissue. We examined Hrk gene expression to clarify the role of BH3-only proteins in apoptosis of retinal ganglion cells (RGCs) after optic nerve transection in the adult rat. Reverse transcription-polymerase chain reaction showed that Hrk was up-regulated in retina from 12 h after axotomy, and continued to be elevated for 1 week. In situ hybridization histochemistry revealed that Hrk was expressed in a sub-population of axotomized RGCs. These results suggest that Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：77 / 80
页数：4
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