Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of Vernonia colorata

被引：24
|
作者：
Chukwujekwu, J. C. [1 ]
Lategan, C. A. [2 ]
Smith, P. J. [2 ]
Van Heerden, F. R. [3 ]
Van Staden, J. [1 ]
机构：
[1] Univ KwaZulu Natal Pietermaritzburg, Sch Biol & Conservat Sci, Res Ctr Plant Growth Dev, ZA-3209 Scottsville, South Africa
[2] Univ Cape Town, Div Pharmacol, Dept Med, ZA-7700 Rondebosch, South Africa
[3] Univ KwaZulu Natal Pietermaritzburg, Sch Chem, ZA-3209 Scottsville, South Africa
来源：
SOUTH AFRICAN JOURNAL OF BOTANY | 2009年 / 75卷 / 01期
基金：
英国医学研究理事会;
关键词：
Antiplasmodial; Cytotoxicity; Vernodalin; Vernolide; Vernonia colorala; MEDICINAL-PLANTS; ASSAY; AMYGDALINA; LEAVES;
D O I：
10.1016/j.sajb.2008.10.001
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Vernonia colorata is used throughout Africa to treat various ailments. Its antiplasmodial activity has been widely reported. Using bioassay-guided fractionation, we isolated two antiplasmodial compounds - vernolide (IC(5)0=1.87 mu g/ml) and vernodalin (IC50=0.52 mu g/ml) with selective indices of 1.02 and 2.79 for vernolide and vernodalin respectively. These compounds are non-specific towards parasites. (C) 2008 SAAB. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：176 / 179
页数：4
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