Stereoselective Synthesis of D-5-Homo-4-selenoribose as a Versatile Intermediate for 4′-Selenonucleosides

被引：11

作者：

Kim, Gyudong ^{[1
]}

Choi, Yoojin ^{[1
]}

Sahu, Pramod K. ^{[1
]}

Yu, Jinha ^{[1
]}

Qu, Shuhao ^{[1
]}

Lee, Dongjoo ^{[2
]}

Jeong, Lak Shin ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[2] Ajou Univ, Coll Pharm, Suwon 443749, South Korea

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

1ST SYNTHESIS; ASYMMETRIC EPOXIDATION; ANTIVIRAL AGENTS; ALCOHOLS; ANALOGS; ACID;

D O I：

10.1021/acs.orglett.5b02393

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective synthesis of D-5-homo-4-selenoribose, serving as a versatile intermediate for the synthesis of 4'-selenonudeosides 12a-c, was accomplished using Sharp less asymmetric epoxidation, regioselective cleavage of the alpha,beta-epoxide, and stereoselective reduction of the ketone as the key steps.

引用

页码：4636 / 4639

页数：4

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