IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans

被引：205

作者：

Conti, Heather R. ^{[1
]}

Gaffen, Sarah L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Med, Div Clin Immunol & Rheumatol, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF IMMUNOLOGY | 2015年 / 195卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CHRONIC MUCOCUTANEOUS CANDIDIASIS; TUMOR-NECROSIS-FACTOR; INNATE LYMPHOID-CELLS; HOST-DEFENSE; TH17; CELLS; T-CELLS; PROTECTIVE IMMUNITY; STAT1; MUTATIONS; HUMAN DECTIN-1; IL-17; PATHWAY;

D O I：

10.4049/jimmunol.1500909

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-17 (IL-17A) has emerged as a key mediator of protection against extracellular microbes, but this cytokine also drives pathology in various autoimmune diseases. Overwhelming data in both humans and mice reveal a clear and surprisingly specific role for IL-17 in protection against the fungus Candida albicans, a commensal microbe of the human oral cavity, gastrointestinal tract, and reproductive mucosa. The IL-17 pathway regulates antifungal immunity through upregulation of proinflammatory cytokines, including IL-6, neutrophilrecruiting chemokines (e.g., CXCL1 and CXCL5), and antimicrobial peptides (e.g., defensins), which act in concert to limit fungal overgrowth. This review focuses on diseases caused by C. albicans, the role of IL-17-mediated immunity in candidiasis, and the implications for clinical therapies for both autoimmune conditions and fungal infections.

引用

下载

页码：780 / 788

页数：9

共 50 条

[31] Genomic Plasticity of the Human Fungal Pathogen Candida albicans
Selmecki, Anna
Forche, Anja
Berman, Judith
EUKARYOTIC CELL, 2010, 9 (07) : 991 - 1008
[32] CSU57 encodes a novel repressor of sorbose utilization in opportunistic human fungal pathogen Candida albicans
Reddy, Praveen Kumar
Pullepu, Dileep
Dhabalia, Darshan
Prakash, Sagunthala Murugesan Udaya
Kabir, Mohammad Anaul
YEAST, 2021, 38 (03) : 222 - 238
[33] Dynamic calcium-mediated stress response and recovery signatures in the fungal pathogen, Candida albicans
Giuraniuc, C. V.
Parkin, C.
Almeida, M. C.
Fricker, M.
Shadmani, P.
Nye, S.
Wehmeier, S.
Chawla, S.
Bedekovic, T.
Lehtovirta-Morley, L.
Richards, D. M.
Gow, N. A.
Brand, A. C.
MBIO, 2023, 14 (05):
[34] The oxidative stress response of the opportunistic fungal pathogen Candida glabrata
Briones-Martin-Del-Campo, Marcela
Orta-Zavalza, Emmanuel
Juarez-Cepeda, Jacqueline
Gutierrez-Escobedo, Guadalupe
Canas-Villamar, Israel
Castano, Irene
De Las Penas, Alejandro
REVISTA IBEROAMERICANA DE MICOLOGIA, 2014, 31 (01): : 67 - 71
[35] Induction of IL-17-mediated cellular immunity targeting MUC1 through vaccination
Larue, Amanda C.
Carrell, Rebecca
McDonald, Lindsay T.
Russell, Dayvia A.
Ethier, Stephen P.
Soloff, Adam C.
CANCER RESEARCH, 2016, 76
[36] Impaired Development of IL-17-Mediated Immunity in a Patient with a Novel STAT1 Mutation
Soltesz, B.
Toth, B.
Csorba, G.
Tasko, S.
Sarkadi, A. K.
Marodi, L.
JOURNAL OF CLINICAL IMMUNOLOGY, 2014, 34 : S175 - S175
[37] The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine
Kumamoto, Carol A.
Gresnigt, Mark S.
Hube, Bernhard
CURRENT OPINION IN MICROBIOLOGY, 2020, 56 : 7 - 15
[38] An improved transformation protocol for the human fungal pathogen Candida albicans
Andrea Walther
Jürgen Wendland
Current Genetics, 2003, 42 : 339 - 343
[39] Oxidative Stress Responses in the Human Fungal Pathogen, Candida albicans
Dantas, Alessandra da Silva
Day, Alison
Ikeh, Melanie
Kos, Iaroslava
Achan, Beatrice
Quinn, Janet
BIOMOLECULES, 2015, 5 (01): : 142 - 165
[40] Polyene susceptibility is dependent on nitrogen source in the opportunistic pathogen Candida albicans
Oliver, Brian G.
Silver, Peter M.
White, Theodore C.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (06) : 1302 - 1308

← 1 2 3 4 5 →