Relapse of multiple sclerosis in a patient retaining CCR7-expressing T cells in CSF under fingolimod therapy

被引：8

作者：

Yokoseki, Akiko ^{[1
]}

Saji, Etsuji ^{[1
]}

Arakawa, Musashi ^{[1
]}

Hokari, Mariko ^{[1
]}

Ishiguro, Takanobu ^{[1
]}

Yanagimura, Fumihiro ^{[1
]}

Ishihara, Tomohiko ^{[1
]}

Okamoto, Kouichirou ^{[2
]}

Nishizawa, Masatoyo ^{[1
]}

Kawachi, Izumi ^{[1
]}

机构：

[1] Niigata Univ, Dept Neurol, Brain Res Inst, Niigata 9518585, Japan

[2] Niigata Univ, Dept Neurosurg, Brain Res Inst, Niigata 9518585, Japan

来源：

MULTIPLE SCLEROSIS JOURNAL | 2013年 / 19卷 / 09期

关键词：

Fingolimod; multiple sclerosis; CCR7; CSF; compartmentalized immune response; FTY720;

D O I：

10.1177/1352458513481395

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor, and it traps lymphocytes in secondary lymphoid organs and precludes their migration into the central nervous system. We report the case of a patient who suffered a relatively severe relapse of multiple sclerosis (MS) during the initial 3 months of fingolimod therapy, with retention of CCR7 expression on CD4(+) T cells in the cerebrospinal fluid (CSF) despite decreased numbers of lymphocytes and decreased expression of CCR7 on CD4(+) T cells in the blood. These data suggest that fingolimod may cause differential effects on the CSF and blood lymphocytes of patients with MS during the initial months of therapy.

引用

页码：1230 / 1233

页数：4

共 27 条

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[26] T cells expressing Th1 associated chemokine receptors CCR5 and CXCR3 are increased in multiple sclerosis, produce high levels of IFN-γ and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions
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