Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

被引：45
|
作者：
Hu, Jun [1 ,2 ]
Yang, Qingjing [1 ,2 ]
Xu, Jianbin [1 ,2 ]
Huang, Chao [1 ,2 ]
Fan, Baomin [1 ,2 ]
Wang, Jun [3 ]
Lin, Chengyuan [3 ]
Bian, Zhaoxiang [3 ,4 ]
Chan, Albert S. C. [4 ]
机构：
[1] Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Chem Ethn Med Resources, Kunming 650500, Peoples R China
[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650500, Peoples R China
[3] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
[4] Hong Kong Baptist Univ, Inst Creat, Hong Kong, Hong Kong, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
RING-OPENING REACTIONS; BICYCLIC ALKENES; OXABICYCLIC ALKENES; 2+2 CYCLOADDITION; NICKEL-COMPLEXES; AZABICYCLIC ALKENES; TERMINAL ALKYNES; EFFICIENT ROUTE; PALLADIUM; DERIVATIVES;
D O I：
10.1039/c2ob26775f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl](2) and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).
引用
收藏
页码：814 / 820
页数：7
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