Observation of sound-induced corneal vibrational modes by optical coherence tomography

被引：40

作者：

Akca, B. Imran ^{[1
,2
]}

Chang, Ernest W. ^{[1
,2
]}

Kling, Sabine ^{[3
]}

Ramier, Antoine ^{[1
,2
,4
]}

Scarcelli, Giuliano ^{[1
,2
,5
]}

Marcos, Susana ^{[3
]}

Yun, Seok H. ^{[1
,2
]}

机构：

[1] Wellman Ctr Photomed, Boston, MA 02140 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA 02140 USA

[3] CSIC, Inst Opt, E-28006 Madrid, Spain

[4] Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] Univ Maryland, Dept Bioengn, College Pk, MD 20742 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2015年 / 6卷 / 09期

基金：

美国国家科学基金会; 美国国家卫生研究院; 欧洲研究理事会;

关键词：

OCULAR RESPONSE ANALYZER; COLLAGEN CROSS-LINKING; BIOMECHANICAL PROPERTIES; ELASTOGRAPHY; KERATOCONUS; MICROSCOPY; ELASTICITY; OCT;

D O I：

10.1364/BOE.6.003313

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanical stability of the cornea is critical for maintaining its normal shape and refractive function. Here, we report an observation of the mechanical resonance modes of the cornea excited by sound waves and detected by using phase-sensitive optical coherence tomography. The cornea in bovine eye globes exhibited three resonance modes in a frequency range of 50-400 Hz. The vibration amplitude of the fundamental mode at 80-120 Hz was similar to 8 mu m at a sound pressure level of 100 dB (2 Pa). Vibrography allows the visualization of the radially symmetric profiles of the resonance modes. A dynamic finite-element analysis supports our observation. (C)c 2015 Optical Society of America

引用

页码：3313 / 3319

页数：7

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