Polyphenols are a class of natural compounds widely distributed in fruits, vegetables, and plants. They have been reported to possess a wide range of activities in prevention and alleviation of various diseases like cancer, neuroinflammation, diabetes, and aging. Polyphenols are effective against chronic diseases and recent reports indicated strong epigenetic effects of polyphenols. Most of the studies investigating epigenetic effects of natural polyphenols have focused on their beneficial effects in cancer treatment. However, epigenetic defects have been demonstrated in many other diseases as well, and application of polyphenols to modulate the epigenome is becoming an interesting field of research. This review summarizes the effects of natural polyphenols in modulating epigenetic-related enzymes as well as their effect in prevention and treatment of chronic diseases with a focus on SIRT1 modulation. We have also discussed the relation between the structure and function of epigenetic-modifying polyphenols.
机构:
Univ Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USAUniv Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USA
Nadtochiy, Sergiy M.
Yao, Hongwei
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Univ Rochester, Dept Environm Med, Med Ctr, Rochester, NY 14642 USAUniv Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USA
Yao, Hongwei
McBurney, Michael W.
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Univ Ottawa, Ctr Canc Therapeut, Ottawa, ON, CanadaUniv Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USA
McBurney, Michael W.
Gu, Wei
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Columbia Univ, Inst Canc Genet, New York, NY USAUniv Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USA
Gu, Wei
Guarente, Leonard
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机构:
MIT, Paul F Glenn Lab, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAUniv Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USA
Guarente, Leonard
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Rahman, Irfan
Brookes, Paul S.
论文数: 0引用数: 0
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机构:
Univ Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USAUniv Rochester, Dept Anesthesiol, Med Ctr, Rochester, NY 14642 USA
Brookes, Paul S.
[J].
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,
2011,
301
(04):
: H1506
-
H1512
机构:
CAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
PUMC, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Chen Houzao
Wan Yanzhen
论文数: 0引用数: 0
h-index: 0
机构:
CAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
PUMC, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Wan Yanzhen
Gao Peng
论文数: 0引用数: 0
h-index: 0
机构:
CAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
PUMC, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Gao Peng
Zhou Shuang
论文数: 0引用数: 0
h-index: 0
机构:
CAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
PUMC, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Zhou Shuang
Zhang Zhuqin
论文数: 0引用数: 0
h-index: 0
机构:
CAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
PUMC, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Zhang Zhuqin
Hao Delong
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机构:
CAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
PUMC, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Hao Delong
Lian Lishan
论文数: 0引用数: 0
h-index: 0
机构:
PUMC, Beijing, Peoples R China
CAMS, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Vasc Surg, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Lian Lishan
Li Yongjun
论文数: 0引用数: 0
h-index: 0
机构:
PUMC, Beijing, Peoples R China
CAMS, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Vasc Surg, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
Li Yongjun
Liu Depei
论文数: 0引用数: 0
h-index: 0
机构:
CAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
PUMC, Beijing, Peoples R ChinaCAMS, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing, Peoples R China
机构:
Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Wan, Yan-Zhen
Gao, Peng
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机构:
Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Gao, Peng
Zhou, Shuang
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机构:
Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Zhou, Shuang
Zhang, Zhu-Qin
论文数: 0引用数: 0
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机构:
Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Zhang, Zhu-Qin
Hao, De-Long
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机构:
Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Hao, De-Long
Lian, Li-Shan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Med Sci, Dept Vasc Surg, Peking Union Med Coll Hosp, Peking Union Med Coll, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Lian, Li-Shan
Li, Yong-Jun
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Chinese Acad Med Sci, Dept Vasc Surg, Peking Union Med Coll Hosp, Peking Union Med Coll, Beijing 100730, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Li, Yong-Jun
Chen, Hou-Zao
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Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Chen, Hou-Zao
Liu, De-Pei
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Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
机构:
Uniwersytet Lodzki, Wydzial Biol & Ochrony Srodowiska, Katedra Genet Mol, Ul Pomorska 141-143, PL-90236 Lodz, PolandUniwersytet Lodzki, Wydzial Biol & Ochrony Srodowiska, Katedra Genet Mol, Ul Pomorska 141-143, PL-90236 Lodz, Poland
Lewandowska, Patrycja
Wozniak, Katarzyna
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机构:
Uniwersytet Lodzki, Wydzial Biol & Ochrony Srodowiska, Katedra Genet Mol, Ul Pomorska 141-143, PL-90236 Lodz, PolandUniwersytet Lodzki, Wydzial Biol & Ochrony Srodowiska, Katedra Genet Mol, Ul Pomorska 141-143, PL-90236 Lodz, Poland