Patterns of acquired mutations in estrogen receptor-positive metastatic breast cancer (MBC) patients identified by comprehensive genomic profiling (CGP)

被引:0
|
作者
McGregor, K. [1 ]
Ross, J. S. [2 ]
Danziger, N. A. [3 ]
Sokol, E. S. [4 ]
Venstrom, J. [5 ]
Chung, J. H. [5 ]
Lee, J. [5 ]
Alexander, B. [5 ]
Schrock, A. B. [5 ]
Tukachinsky, H. [1 ]
机构
[1] Fdn Med Inc, Med Affairs, Boston, MA USA
[2] Fdn Med, Cambridge, MA USA
[3] Fdn Med Inc, Pathol, Cambridge, MA USA
[4] Fdn Med Inc, Canc Genom, Cambridge, MA USA
[5] Fdn Med, Clin Dev, Boston, MA USA
关键词
D O I
10.1016/j.annonc.2020.08.407
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
305P
引用
收藏
页码:S364 / S364
页数:1
相关论文
共 50 条
  • [21] Comprehensive biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers
    Spoerke, Jill M.
    Schleifman, Erica B.
    Desai, Rupal
    Xiao, Yuanyuan
    Wong, Cheryl
    Abbas, Ilma
    O'Brien, Carol
    Patel, Rajesh
    Sumiyoshi, Teiko
    Fu, Ling
    Tam, Rachel
    Koeppen, Hartmut
    Wilson, Timothy
    Raja, Rajiv
    Hampton, Garret M.
    Lackner, Mark R.
    MOLECULAR CANCER RESEARCH, 2013, 11
  • [22] Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine
    Levin, Maren K.
    Wang, Kai
    Yelensky, Roman
    Cao, Ying
    Ramos, Corinne
    Hoke, Nicholas
    Pippen, John, Jr.
    Blum, Joanne L.
    Brooks, Barry
    Palmer, Gary
    Palma, Norma
    Balasubramanian, Sohail
    Ross, Jeffrey S.
    O'Shaughnessy, Joyce
    CANCER MEDICINE, 2015, 4 (08): : 1289 - 1293
  • [23] Emergence of Constitutively Active Estrogen Receptor-α Mutations in Pretreated Advanced Estrogen Receptor-Positive Breast Cancer
    Jeselsohn, Rinath
    Yelensky, Roman
    Buchwalter, Gilles
    Frampton, Garrett
    Meric-Bernstam, Funda
    Gonzalez-Angulo, Ana Maria
    Ferrer-Lozano, Jaime
    Perez-Fidalgo, Jose A.
    Cristofanilli, Massimo
    Gomez, Henry
    Arteaga, Carlos L.
    Giltnane, Jennifer
    Balko, Justin M.
    Cronin, Maureen T.
    Jarosz, Mirna
    Sun, James
    Hawryluk, Matthew
    Lipson, Doron
    Otto, Geoff
    Ross, Jeffrey S.
    Dvir, Addie
    Soussan-Gutman, Lior
    Wolf, Ido
    Rubinek, Tamar
    Gilmore, Lauren
    Schnitt, Stuart
    Come, Steven E.
    Pusztai, Lajos
    Stephens, Philip
    Brown, Myles
    Miller, Vincent A.
    CLINICAL CANCER RESEARCH, 2014, 20 (07) : 1757 - 1767
  • [24] Prognostic Value of ModifiedIHC4Score in Patients with Estrogen Receptor-Positive Metastatic Breast Cancer
    Jin, Liang
    Chen, Kai
    Tan, Cui
    Li, Jianbin
    Luo, Jiayue
    Yang, Yaping
    Li, Yudong
    Li, Shunying
    Zhu, Liling
    Hu, Yue
    Liu, Fengtao
    You, Qiuting
    Peng, Min
    Jiang, Zefei
    Liu, Qiang
    ONCOLOGIST, 2020, 25 (08): : E1170 - E1180
  • [25] Efficacy of fulvestrant in treating postmenopausal patients with estrogen receptor-positive metastatic breast cancer and prognostic analysis
    Li, Tao
    Jiao, Lianghe
    JOURNAL OF BUON, 2021, 26 (01): : 189 - 195
  • [26] Phase I study of TTC-352 in patients with estrogen receptor-positive metastatic breast cancer
    ORegan, Ruth M.
    Hurley, Randolph
    Sachdev, Jasgit C.
    Bleeker, Jonathan
    Tonetti, Debra
    Thatcher, Gregory
    Venuti, Robert
    Dudek, Arkadiusz Z.
    CANCER RESEARCH, 2019, 79 (13)
  • [27] Progression of genomic signatures in local and metastatic estrogen receptor-positive (ER plus ) breast cancer: Relevance to palliative treatment
    Symmans, William Fraser
    Andreopoulou, Eleni
    Booser, Daniel J.
    Hatzis, Christos
    Wallace, Michael J.
    Zhang, Ya
    Gong, Yun
    Ignatiadis, Michail
    Sotiriou, Christos
    Andre, Fabrice
    Peintinger, Florentina
    Regitnig, Peter
    Marth, Christian
    Desmedt, Christine
    Loi, Sherene
    Moulder, Stacy L.
    Hortobagyi, Gabriel N.
    Pusztai, Lajos
    Valero, Vicente
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [28] Comprehensive genomic profiling (CGP) in breast cancer (BC): Patterns and results from a clinico-genomic database.
    Rody, Achim
    Chaudhary, Nayan
    Craggs, Christopher
    Debiasi, Marcio
    Erb, Gilles
    Fisher, Virginia
    McCusker, Margaret
    Snow, Tamara
    Vidal Losada, Maria
    Luhn, Patricia
    CANCER RESEARCH, 2021, 81 (13)
  • [29] Estrogen receptor-positive (ER plus ) metastatic breast cancer (MBC) patients (pts) with extreme responses (ERs) to capecitabine having tumors with genomic alterations in DNA repair and chromatin remodeling genes
    Levin, Maren K.
    Wang, Kai
    Yelensky, Roman
    Cao, Ying
    Ramos, Corinne
    Hoke, Glenn D.
    Pippen, John E.
    Blum, Joanne Lorraine
    Brooks, Barry Don
    Palmer, Gary A.
    Palma, Norma Alonzo
    Balasubramanian, Sohail
    Ross, Jeffrey S.
    O'Shaughnessy, Joyce
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [30] Bicalutamide Plus Aromatase Inhibitor in Patients with Estrogen Receptor-Positive/Androgen Receptor-Positive Advanced Breast Cancer
    Lu, Qianyi
    Xia, Wen
    Lee, Kaping
    Zhang, Jingmin
    Yuan, Huimin
    Yuan, Zhongyu
    Shi, Yanxia
    Wang, Shusen
    Xu, Fei
    ONCOLOGIST, 2020, 25 (01): : 21 - +