Ursolic acid: Pharmacokinetics process in vitro and in vivo, a mini review

被引：52
|
作者：
Wen Jinhua [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 1, Dept Pharm, Nanchang 330006, Jiangxi, Peoples R China
来源：
ARCHIV DER PHARMAZIE | 2019年 / 352卷 / 03期
基金：
中国国家自然科学基金;
关键词：
absorption; distribution; elimination; pharmacokinetics; ursolic acid; POLOXAMER; 407; LIPOSOMES; EFFICACY; ENHANCE;
D O I：
10.1002/ardp.201800222
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. UA has a widespread pharmacologic effect, including antitumor, anti-inflammatory, anti-oxidant, anti-apoptotic, anti-allergy, and anti-carcinogenic effects. UA can be used as an alternative medicine for the treatment and prevention of many diseases. However, the bioavailability of UA by oral administration is low since it is absorbed by the intestine through passive diffusion. Therefore, some novel technologies are used to produce UA preparations that can change the pharmacokinetics process and increase its solubility and bioavailability. At present, pharmacokinetic studies on UA are few. In this paper, we will review the pharmacokinetics features of free UA and some novel UA preparations in vitro and in vivo, in order to provide a reference for rational utilization and drug design of UA.
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页数：5
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