Bisorbibetanone, a novel oxidized sorbicillin dimer, with 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity from a fungus

被引：31
|
作者：
Abe, N [1 ]
Murata, T [1 ]
Yamamoto, K [1 ]
Hirota, A [1 ]
机构：
[1] Univ Shizuoka, Sch Food & Nutr Sci, Appl Microbiol Lab, Shizuoka 4228526, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 28期
关键词：
polyketide; fungi; stereochemistry; dimers;
D O I：
10.1016/S0040-4039(99)00938-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We isolated a novel oxidized sorbicillin dimer (1) as yellowish amorphous powder from the fermentation broth of Trichoderma sp. USF-2690 strain isolated from a soil sample. The structure of the compound was determined by elucidation of spectroscopic evidence. The compound was revealed to possess a new carbon skeleton in the group of oxidized sorbicillin dimers and was named bisorbibetanone. The stereostructure of bisorbibetanone was analyzed on the basis of the spectral data. In 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, bisorbibetanone gave an ED50 value of 62.5 mu M after standing for 30 min. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5203 / 5206
页数：4
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