Carfilzomib-Lenalidomide-Dexamethasone (KRd) Induction-Autologous Transplant (ASCT)-Krd Consolidation Vs KRd 12 Cycles Vs Carfilzomib-Cyclophosphamide-Dexamethasone (KCd) Induction-ASCT-KCd Consolidation: Analysis of the Randomized Forte Trial in Newly Diagnosed Multiple Myeloma (NDMM)

被引:22
|
作者
Gay, Francesca [1 ]
Cerrato, Chiara [1 ]
Scalabrini, Delia Rota [1 ]
Galli, Monica [1 ]
Belotti, Angelo [1 ]
Zamagni, Elena [1 ]
Ledda, Antonio [1 ]
Grasso, Mariella [1 ]
Angelucci, Emanuele [1 ]
Liberati, Anna Marina [1 ]
Tosi, Patrizia [1 ]
Pisani, Francesco [1 ]
Spada, Stefano [1 ]
Annibali, Ombretta [1 ]
Baraldi, Anna [1 ]
Omede, Paola [1 ]
Galieni, Piero [1 ]
Rizzi, Rita [1 ]
Pescosta, Norbert [1 ]
Ronconi, Sonia [1 ]
Vincelli, Donatella [1 ]
Cafro, Anna Maria [1 ]
Offidani, Massimo [1 ]
Palumbo, Antonio [2 ,3 ]
Musto, Pellegrino [1 ]
Cavo, Michele [1 ]
Boccadoro, Mario [1 ]
机构
[1] European Myeloma Network, GIMEMA, Milan, Italy
[2] Univ Torino, Turin, Italy
[3] Takeda Pharmaceut Co, Zurich, Switzerland
关键词
D O I
10.1182/blood-2018-99-112093
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
121
引用
收藏
页数:4
相关论文
共 50 条
  • [41] Carfilzomib-lenalidomide-dexamethasone Vs. lenalidomide-dexamethasone in non-frail transplant-ineligible patients with newly diagnosed multiple myeloma: the EMN20 trial
    D'Agostino, Mattia
    Antonioli, Elisabetta
    Gamberi, Barbara
    Bruno, Benedetto
    Derudas, Daniele
    Tosi, Patrizia
    Fazio, Francesca
    Carlo-Stella, Carmelo
    Ronconi, Sonia
    Corradini, Paolo
    Ballanti, Stelvio
    Cellini, Claudia
    Falcone, Antonietta Pia
    Bringhen, Sara
    Offidani, Massimo
    Rambaldi, Alessandro
    Rota-Scalabrini, Delia
    Agazzi, Alberto
    Casaluci, Gloria Margiotta
    Pietrantuono, Giuseppe
    Patriarca, Francesca
    Larocca, Alessandra
    Boccadoro, Mario
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S94 - S95
  • [42] Carfilzomib-Lenalidomide-Dexamethasone (KRd) Vs. Lenalidomide-Dexamethasone (Rd) in Newly Diagnosed Fit or Intermediate-Fit Multiple Myeloma Patients Not Eligible for Autologous Stem-Cell Transplantation (Phase III EMN20 Trial): Analysis of Sustained Undetectable Minimal Residual Disease (MRD)
    Bringhen, Sara
    Antonioli, Elisabetta
    Gamberi, Barbara
    Bruno, Benedetto
    Derudas, Daniele
    Tosi, Patrizia
    Fazio, Francesca
    Mazza, Rita
    Ronconi, Sonia
    Corradini, Paolo
    Lotti, Flavia
    Cellini, Claudia
    Falcone, Antonietta Pia
    Galieni, Piero
    Ria, Roberto
    Belotti, Angelo
    Mannina, Donato
    Cafro, Anna Maria
    Cangialosi, Clotilde
    Vincelli, Iolanda Donatella
    Lombardo, Alessandra
    Larocca, Alessandra
    Boccadoro, Mario
    D'Agostino, Mattia
    BLOOD, 2023, 142
  • [43] Planned Interim Analysis of the GMMG-CONCEPT Trial investigating Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone (Isa-KRd) in Patients with High-Risk Newly Diagnosed Multiple Myeloma
    Leypoldt, L.
    Besemer, B.
    Haenel, M.
    Raab, M. -S
    Mann, C.
    Munder, M.
    Reinhardt, H. C.
    Nogai, A.
    Goerner, M.
    Ko, Y. -D
    de Wit, M.
    Salwender, H.
    Scheid, C.
    Graeven, U.
    Peceny, R.
    Staib, P.
    Dieing, A.
    Einsele, H.
    Jauch, A.
    Zago, M.
    Benner, A.
    Tichy, D.
    Bokemeyer, C.
    Goldschmidt, H.
    Weisel, K.
    ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 55 - 56
  • [44] Phase II MMRC trial of extended treatment with carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (DEX) plus autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma (NDMM).
    Zimmerman, Todd M.
    Griffith, Kent A.
    Jasielec, Jagoda
    Rosenbaum, Cara Ann
    McDonnell, Kathryn
    Waite-Marin, Jessica
    Berdeja, Jesus G.
    Raje, Noopur S.
    Reece, Donna Ellen
    Vij, Ravi
    Alonge, Mattina
    Rosebeck, Shaun
    Gurbuxani, Sandeep
    Faham, Malek
    Kong, Katherine A.
    Levy, Joan
    Jakubowiak, Andrzej J.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [45] Carfilzomib Combined with Thalidomide and Low-Dose Dexamethasone for Remission Induction and Consolidation in Newly Diagnosed, Transplant Eligible Patients with Multiple Myeloma: The Carthadex Trial
    Wester, Ruth
    van der Holt, Bronno
    Asselbergs, Emelie
    Zweegman, Sonja
    Kersten, Marie Jose
    Vellenga, Edo
    Kooij, Marinus van Marwijk
    de Weerdt, Okke
    Minnema, Monique C.
    Lonergan, Sarah
    Palumbo, Antonio
    Lokhorst, Henk M.
    Broyl, Annemiek
    Iskander, Karim Saad
    Sonneveld, Pieter
    BLOOD, 2017, 130
  • [46] GEM2017FIT Trial: Induction Therapy with Bortezomib-Melphalan and Prednisone (VMP) Followed By Lenalidomide and Dexamethasone (Rd) Versus Carfilzomib, Lenalidomide and Dexamethasone (KRd) Plus/Minus Daratumumab (D), 18 Cycles, Followed By Consolidation and Maintenance Therapy with Lenalidomide and Daratumumab: Phase III, Multicenter, Randomized Trial for Elderly Fit Newly Diagnosed Multiple Myeloma (NDMM) Patients Aged between 65 and 80 Years
    Mateos, Maria-Victoria
    Paiva, Bruno
    Cedena Romero, Maria Teresa
    Puig, Noemi
    Sureda Balari, Anna Maria
    Oriol, Albert
    Ocio, Enrique M.
    Rosinol, Laura
    Gonzalez-Montes, Yolanda
    Jose Bargay, Juan
    Gonzalez Garcia, Esther
    Hernandez Garcia, Miguel Teodoro
    Ramirez, Angel
    Suarez-Cabrera, Alexia
    Blanchard, Maria-Jesus
    Garzon, Sebastian
    Casado Montero, Luis Felipe
    Cabanas Perianes, Valentin
    Perez De Oteyza, Jaime
    Gironella, Mercedes
    Martinez-Lopez, Joaquin
    Ana-Isabel-Teruel
    Delgado, Pilar
    Prieto, Elena
    Lahuerta Palacios, Juan Jose
    Blade, Joan
    San Miguel, Jesus
    BLOOD, 2023, 142
  • [47] Outcomes of MRD-Adapted Treatment Modulation in Patients with Newly Diagnosed Multiple Myeloma Receiving Daratumumab, Carfilzomib, Lenalidomide and Dexamethasone (Dara-KRd) and Autologous Transplantation: Extended Follow up of the Master Trial
    Costa, Luciano J.
    Chhabra, Saurabh
    Medvedova, Eva
    Schmidt, Timothy Martin
    Dholaria, Bhagirathbhai
    Godby, Kelly N.
    Silbermann, Rebecca
    Bal, Susan
    D'Souza, Anita
    Giri, Smith
    Omel, James L.
    Hari, Parameswaran
    Callander, Natalie
    Dhakal, Binod
    BLOOD, 2022, 140 : 7275 - 7277
  • [48] Depth of response to Isatuximab, Carfilzomib, Lenalidomide and Dexamethasone (Isa-KRd) in front-line induction of high-risk Multiple Myeloma: Interim analysis of the GMMG-CONCEPT trial
    Weisel, K. C.
    Asemissen, A. M.
    Leypoldt, L.
    Besemer, B.
    Haenel, M.
    Blau, I. W.
    Goerner, M.
    Ko, Y. -D.
    Duerig, J.
    Staib, P.
    Mann, C.
    Lutz, R.
    Munder, M.
    Graeven, U.
    Peceny, R.
    Salwender, H.
    Zago, M.
    Benner, A.
    Tichy, D.
    Bokemeyer, C.
    Goldschmidt, H.
    ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 (SUPPL 4) : 91 - 92
  • [49] Phase 2 Study of Carfilzomib, Thalidomide, and Low-Dose Dexamethasone As Induction/Consolidation in Newly Diagnosed, Transplant Eligible Patients with Multiple Myeloma, the Carthadex Trial
    Wester, Ruth
    van der Holt, Bronno
    Asselbergs, Emelie
    van Duin, Mark
    Zweegman, Sonja
    Kersten, Marie Jose
    Vellenga, Edo
    Kooy, Marinus van Marwijk
    de Weerdt, Okke
    Minnema, Monique
    Lonergan, Sarah
    Palumbo, Antonio
    Lokhorst, Henk M.
    Broijl, Annemiek
    Sonneveld, Pieter
    BLOOD, 2016, 128 (22)
  • [50] Phase II study of carfilzomib, thalidomide, and low-dose dexamethasone as induction and consolidation in newly diagnosed, transplant eligible patients with multiple myeloma; the Carthadex trial
    Wester, Ruth
    van der Holt, Bronno
    Asselbergs, Emelie
    Zweegman, Sonja
    Kersten, Marie Jose
    Vellenga, Edo
    Kooy, Marinus van Marwijk
    de Weerdt, Okke
    Minnema, Monique
    Lonergan, Sarah
    Palumbo, Antonio
    Lokhorst, Henk
    Broijl, Annemiek
    Sonneveld, Pieter
    HAEMATOLOGICA, 2019, 104 (11) : 2265 - 2273