Aurora Kinase Inhibitors in Head and Neck Cancer

被引：2

作者：

Qi, Guangying ^{[1
]}

Liu, Jing ^{[1
]}

Mi, Sisi ^{[1
]}

Tsunematsu, Takaaki ^{[2
]}

Jin, Shengjian ^{[1
]}

Shao, Wenhua ^{[1
]}

Liu, Tian ^{[1
]}

Ishimaru, Naozumi ^{[2
]}

Tang, Bo ^{[1
]}

Kudo, Yasusei ^{[2
]}

机构：

[1] Guilin Med Univ, Affiliated Hosp, Dept Pathol & Physiopathol Hepatobiliary Surg, Guilin 541000, Peoples R China

[2] Univ Tokushima, Inst Biomed Sci, Dept Oral Mol Pathol, Grad Sch, Tokushima 7708504, Japan

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Aurora kinases; Mitosis; Head and neck cancer; Aurora kinase inhibitor; Tumor; Biological function; SMALL-MOLECULE INHIBITOR; ACUTE MYELOID-LEUKEMIA; CHROMOSOMAL PASSENGER PROTEIN; SPINDLE ASSEMBLY CHECKPOINT; HUMAN COLORECTAL CANCERS; SUPPRESSES TUMOR-GROWTH; CELLS IN-VITRO; SELECTIVE AURORA; B-KINASE; A KINASE;

D O I：

10.2174/1568026618666180112163741

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

引用

页码：199 / 213

页数：15

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