Siegesbeckia pubescens ameliorates experimental ulcerative colitis in rats by modulating PPARγ

被引：0
|
作者：
Teng, Tianli [1 ,3 ]
Xu, Shifang [1 ]
Chen, Qun [2 ]
Chen, Fengyang [1 ]
Li, Xiaoyu [1 ]
Gao, Lijuan [1 ]
Hao, Shujuan [1 ]
Ye, Yiping [1 ]
机构：
[1] Zhejiang Acad Med Sci, Inst Materia Med, Tianmushan Rd 182, Hangzhou 310013, Zhejiang, Peoples R China
[2] Ningbo Coll Hlth Sci, Ningbo 315100, Zhejiang, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Pharm, Hangzhou 310003, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 12期
基金：
美国国家科学基金会;
关键词：
Siegesbeckia pubescens; ulcerative colitis; TNBS; PPAR gamma; ACTIVATED RECEPTOR-GAMMA; NF-KAPPA-B; INDUCED MODEL; ENT-KAURANE; INFLAMMATION; DITERPENOIDS; HETERODIMER; MACROPHAGES; MECHANISMS; EXPRESSION;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Siegesbeckia pubescens is a traditional Chinese medicine widely used for the treatment of inflammatory and autoimmune diseases in clinic. In order to evaluate its therapeutic effect against ulcerative colitis (UC) and elucidate its possible mechanisms, in this study, the effect of aqueous extract of S. pubescens (SPA) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced experimental UC in rats was determined. The results showed that oral administration of SPA significantly ameliorated colonic edema, hyperemia, inflammation and anabrosis in TNBS-induced experimental UC in rats. In addition, SPA inhibited MPO and pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6 and IFN-gamma) production, and up-regulated PPAR. expression in colon. These results indicated that SPA has therapeutic effects against TNBS-induced experimental UC in rats, and its underlying mechanisms involve the modulation of PPAR gamma-mediated production of inflammatory mediators. These findings highlight the potential of this traditional Chinese medicine as an agent for use in the treatment of UC.
引用
收藏
页码：23082 / 23091
页数：10
相关论文
共 50 条
  • [11] ?INDIGO NATURALIS' AMELIORATES ULCERATIVE COLITIS VIA MODULATING AHR SIGNALING AND MICROBE COMPOSITION
    Yoshimatsu, Yusuke
    Teratani, Toshiaki
    Sujino, Tomohisa
    Mikami, Yohei
    Takada, Yoshiaki
    Hagihara, Yuya
    Tanemoto, Shun
    Umeda, Satoko
    Nomura, Ena
    Yoshida, Kosuke
    Ohno, Keiko
    Sugimoto, Shinya
    Nanki, Kosaku
    Mizuno, Shinta
    Naganuma, Makoto
    Kanai, Takanori
    GASTROENTEROLOGY, 2019, 156 (06) : S1118 - S1118
  • [12] Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats
    Cellat, Mustafa
    Tekeli, Ibrahim Ozan
    Turk, Erdinc
    Aydin, Tuba
    Uyar, Ahmet
    Isler, Cafer Tayer
    Gokcek, Ishak
    Etyemez, Muhammed
    Guvenc, Mehmet
    BIOTECHNIC & HISTOCHEMISTRY, 2023, 98 (04) : 255 - 266
  • [13] Keratinocyte growth factor gene therapy ameliorates ulcerative colitis in rats
    Chun-Jie Liu
    World Journal of Gastroenterology, 2011, 17 (21) : 2632 - 2640
  • [14] Keratinocyte growth factor gene therapy ameliorates ulcerative colitis in rats
    Liu, Chun-Jie
    Jin, Ji-De
    Lv, Tong-De
    Wu, Zu-Ze
    Ha, Xiao-Qin
    WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (21) : 2632 - 2640
  • [15] Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
    Bai, Yongfeng
    Wang, Siwei
    Xu, Wenkai
    Weng, Yuanyuan
    Zhu, Shengmei
    Sheng, Hao
    Zhu, Jin
    Zhang, Feng
    PLOS ONE, 2019, 14 (09):
  • [16] The inhibition of IKB kinase ameliorates experimental colitis in rats
    Nogales, A. R.
    Algieri, F.
    Garrido-Mesa, J.
    Utrilla, P.
    Rodriguez-Cabezas, M.
    Thiemermann, C.
    Galvez, J.
    IMMUNOLOGY, 2014, 143 : 37 - 38
  • [17] Paeonol alleviates ulcerative colitis by modulating PPAR-γ and nuclear factor-κB activation
    Cheng, Shuyu
    Chen, Wujin
    Guo, Zhenzhen
    Ding, Chenchun
    Zuo, Renjie
    Liao, Quan
    Liu, Guoyan
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [18] Gancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites
    Luo, Yi-Ting
    Wu, Jin
    Zhu, Fang-Yuan
    Wu, Jia-Qian
    Wu, Pei
    Liu, Ying-Chao
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2022, 16 : 1383 - 1405
  • [19] Camel Milk Protein Ameliorates Ulcerative Colitis by Modulating Gut Microbiota and Amino Acid Metabolism
    Kang, Ning
    Fan, Zhexin
    Yang, Li
    Shen, Jie
    Shen, Yuechenfei
    Fang, Zhifeng
    Li, Baokun
    Yang, Bo
    Wang, Jiancheng
    NUTRIENTS, 2025, 17 (05)
  • [20] Lizhong decoction ameliorates ulcerative colitis in mice via modulating gut microbiota and its metabolites
    Junfeng Zou
    Yumeng Shen
    Mengjun Chen
    Zhimiao Zhang
    Suwei Xiao
    Chen Liu
    Yue Wan
    Lei Yang
    Shu Jiang
    Erxin Shang
    Dawei Qian
    Jinao Duan
    Applied Microbiology and Biotechnology, 2020, 104 : 5999 - 6012
12345