Enzymatic syntheses of 3'-halotyramines, selectively 2H- and 3H-labeled in the side chain

被引：6
|
作者：
Pajak, Malgorzata [1 ]
Kanska, Marianna [2 ]
机构：
[1] Warsaw Univ, Dept Chem, Pasteur 1 Str, PL-02093 Warsaw, Poland
[2] Med Univ Warsaw, Fac Med 2, Dept Biochem, 61 Zwirki & Wigwy Av, PL-02091 Warsaw, Poland
来源：
APPLIED RADIATION AND ISOTOPES | 2018年 / 131卷
关键词：
Deuterium; Enzyme; Labeling; Tritium; Tyramine; STEREOCHEMISTRY; METABOLISM; TRANSPORT; EXCHANGE; TYROSINE; ACIDS;
D O I：
10.1016/j.apradiso.2017.10.032
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
3'-Halotyramines, stereo-selectively labeled with deuterium and tritium, in the (1R) or (IS) position were synthesized using enzymatic methods. The isotopomers labeled in the (1R) position were synthesized by enzymatic decarboxylation of an appropriate 3'-halo-L-tyrosine in deuterated or tritiated incubation medium. The isotopomers labeled in the (1S) position were synthesized by decarboxylation of an appropriate 3'-halo-L-tyrosine, labeled with deuterium or tritium in the alpha-position of the side chain.
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页码：8 / 12
页数：5
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