Development of novel, selective and irreversible PI3Kδ inhibitors

被引：0
|
作者：
Dalton, Samuel [1 ,2 ]
Campos, Sebastien [2 ]
Bush, Jacob [2 ]
Thomas, Daniel [2 ]
Convery, Maire [2 ]
Murphy, John [1 ]
机构：
[1] Univ Strathclyde Appl Chem, Glasgow, Lanark, Scotland
[2] GlaxoSmithKline, Stevenage, Herts, England
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 252卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
264
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Selective PI3Kδ inhibitors, a review of the patent literature
    Norman, Peter
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2011, 21 (11) : 1773 - 1790
  • [22] PI3K Isoform-Selective Inhibitors in Cancer
    Duncan, Leslie
    Shay, Chloe
    Teng, Yong
    [J]. SINGLE-CELL SEQUENCING AND METHYLATION: METHODS AND CLINICAL APPLICATIONS, 2020, 1255 : 165 - 173
  • [23] Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors
    Methot, Joey L.
    Achab, Abdelghani
    Christopher, Matthew
    Zhou, Hua
    McGowan, Meredeth A.
    Trotter, B. Wesley
    Fradera, Xavier
    Lesburg, Charles A.
    Goldenblatt, Peter
    Hill, Armetta
    Chen, Dapeng
    Otte, Karin M.
    Augustin, Martin
    Shah, Sanjiv
    Katz, Jason D.
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (12): : 2461 - 2469
  • [24] Identification of highly potent and selective PI3Kδ inhibitors
    Marcoux, David
    Quin, Lan-Ying
    Ruan, Zheming
    Shi, Qing
    Ruan, Qian
    Weigelt, Carolyn
    Qiu, Hongchen
    Schieven, Gary
    Hynes, John
    Bhide, Rajeev
    Poss, Michael
    Tino, Joseph
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (13) : 2849 - 2853
  • [25] Highly delta selective quinazolinone PI3K inhibitors
    Treiberg, Jennifer
    Chandrasekhar, Jayaraman
    Ip, Carmen
    Koditek, David
    Lepist, Eve-Irene
    McGrath, Mary
    Mwangi, Judy
    Perreault, Stephane
    Somoza, John
    Steiner, Bart
    Therrien, Joseph
    Villasenor, Armando
    Wise, Sarah
    Wong, Belinda
    Phillips, Gary
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [26] Biomarker evaluation In phase I clinical trials of selective PI3K and PI3K/mTOR inhibitors
    Spoerke, Jill
    O'Brien, Carol
    Wu, Jenny
    Desai, Rupal
    Patel, Rajesh
    Raja, Rajiv
    Koeppen, Hartmut
    Amler, Lukas
    Hampton, Garret
    Yan, Yibing
    Lackner, Mark R.
    [J]. CANCER RESEARCH, 2012, 72
  • [27] Biomarker evaluation in phase I clinical trials of selective PI3K and PI3k/mTOR inhibitors
    Spoerke, Jill
    Desai, Rupal
    Patel, Rajesh
    Fredrickson, Jill
    Wang, Yulei
    Levy, Gallia
    Gendreau, Steve
    Lauchle, Jennifer
    Derynck, Mika
    Raja, Rajiv
    Koeppen, Hartmut
    Hampton, Garret
    Yan, Yibing
    Lackner, Mark R.
    [J]. CANCER RESEARCH, 2013, 73 (08)
  • [28] Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
    Bruce, Ian
    Akhlaq, Mohammed
    Bloomfield, Graham C.
    Budd, Emma
    Cox, Brian
    Cuenoud, Bernard
    Finan, Peter
    Gedeck, Peter
    Hatto, Julia
    Hayler, Judy F.
    Head, Denise
    Keller, Thomas
    Kirman, Louise
    Leblanc, Catherine
    Le Grand, Darren
    McCarthy, Clive
    O'Connor, Desmond
    Owen, Charles
    Oza, Mrinalini S.
    Pilgrim, Gaynor
    Press, Nicola E.
    Sviridenko, Lilya
    Whitehead, Lewis
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (17) : 5445 - 5450
  • [29] Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Selective PI3Kβ Inhibitors
    Cao, Shuang
    Cao, Ruiyuan
    Liu, Xialing
    Luo, Xiang
    Zhong, Wu
    [J]. MOLECULES, 2016, 21 (07)
  • [30] Discovery of Novel Azaindoles as Potent and Selective PI3Kδ Inhibitors for Treatment of Multiple Sclerosis
    Yu, Mengyao
    Wang, Xian
    Tang, Yongmei
    Wang, Longling
    Hu, Xueping
    Weng, Qinjie
    Wang, Jiajia
    Cui, Sunliang
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (11) : 9628 - 9644
12345