Copper-catalyzed four-component synthesis of imidazo[1,2-a]pyridines via sequential reductive amination, condensation, and cyclization

被引：28

作者：

Allahabadi, Emad ^{[1
]}

Ebrahimi, Sina ^{[1
]}

Soheilizad, Mehdi ^{[2
]}

Khoshneviszadeh, Mehdi ^{[3
]}

Mahdavi, Mohammad ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran 14176, Iran

[2] Univ Tehran, Sch Chem, Coll Sci, POB 14155-6455, Tehran, Iran

[3] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 02期

基金：

美国国家科学基金会;

关键词：

Copper-catalyzed; Imidazo[1,2-a]pyridine; Reductive amination; 2-Bromopyridine; Aldehyde; Isocyanide; Sodium azide; ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; DERIVATIVES; BINDING; 2-AMINOPYRIDINES; INHIBITORS; ZOLPIDEM; AFFINITY; ALPIDEM; SNAR;

D O I：

10.1016/j.tetlet.2016.11.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient four -component approach for the synthesis of 2,3-disubstituted imidazo[1,2-a] pyridines is described. The copper -catalyzed reductive amination of 2-bromopyridine by sodium azide followed by sequential condensation and cyclization with aldehydes and isocyanides afforded the corresponding imidazo[1,2-alpyridines in good yields. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：121 / 124

页数：4

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