Red blood cell sedimentation rate measurements in a high aspect ratio microchannel

被引：2

作者：

Passos, Andreas ^{[1
]}

Louka, Marinos ^{[1
]}

Vryonidis, Charalambos ^{[1
]}

Inglezakis, Antonis ^{[2
]}

Loizou, Constantinos ^{[2
]}

Nikiphorou, Elena ^{[3
,4
]}

Psarelis, Savvas ^{[5
]}

Kaliviotis, Efstathios ^{[1
]}

机构：

[1] Cyprus Univ Technol, Dept Mech Engn & Mat Sci & Engn, 45 Kitiou Kyprianou, CY-3041 Limassol, Cyprus

[2] EMBIO Diagnost Ltd, Nicosia, Cyprus

[3] Kings Coll London, Ctr Rheumat Dis, London, England

[4] Kings Coll Hosp London, Rheumatol Dept, London, England

[5] Minist Hlth Cyprus, Nicosia, Cyprus

来源：

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | 2022年 / 82卷 / 04期

关键词：

Erythrocyte sedimentation rate (ESR); micro-ESR; microfluidics; surface tension driven flow; point-of-care; PLASMA VISCOSITY; RATE ESR; ERYTHROCYTE; HEMATOCRIT;

D O I：

10.3233/CH-221476

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: The erythrocyte sedimentation rate (ESR) test is commonly used in clinical practice for monitoring, screening and diagnosing pathological conditions and diseases related to the inflammatory response of the immune system. Several ESR techniques have been developed over the years improving the reliability, the precision and the duration of the measurement. OBJECTIVE: In the present study a new low cost micro-ESR technique is described providing the major advantage of reducing the measurement time and the blood sample volume by multiple times compared to the commercial methods. METHODS: Blood samples were obtained from healthy donors within the age group of 24-28 years and the haematocrit was adjusted to 30%, 40% and 50%. The ESR of the samples was measured utilizing a surface tension driven (STD) microfluidic chip and a monitoring device. RESULTS: The evaluation of the method showed a high correlation (0.94, p< 10(-5)) at all haematocrit levels with the commercial instrument indicating the feasibility of the technique.

引用

页码：313 / 322

页数：10

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