Vesicular Acetylcholine Transporter (VAChT) in the Brain of Spontaneously Hypertensive Rats (SHR): Effect of Treatment with an Acetylcholinesterase Inhibitor

被引：10
|
作者：
Tayebati, S. K. [1 ]
Di Tullio, M. A. [1 ]
Amenta, F. [1 ]
机构：
[1] Univ Camerino, Dept Expt Med & Publ Hlth, Sect Human Anat, I-62032 Camerino, Italy
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2008年 / 30卷 / 08期
关键词：
cholinergic system; hypertension; adult-onset disorders; vascular dementia; cerebral areas; VAChT;
D O I：
10.1080/10641960802580216
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The cholinergic marker vesicular acetylcholine transporter (VAChT) was investigated in different cerebral areas of spontaneously hypertensive rats (SHR) by immunochemistry (Western blot analysis) and by immunohistochemistry. SHR were used as an animal model of hypertensive brain damage. The sensitivity of manipulation of cholinergic system on VAChT was assessed in rats treated for four weeks with the acetylcholinesterase (AChE) inhibitor galantamine (3 mg/Kg/day). VAChT concentrations were increased in the brain of control SHR compared to age-matched normotensive Wistar-Kyoto rats. This increase probably represents an up-regulation of VAChT to oppose cholinergic deficits reported in SHR and is countered by galantamine administration. The possibility that cholinergic neurotransmission enhancement may represent a therapeutic strategy in cerebrovascular disease is discussed.
引用
收藏
页码：732 / 743
页数：12
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