The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

被引:194
|
作者
Burnstock, Geoffrey [1 ,2 ,3 ]
Knight, Gillian E. [1 ]
机构
[1] UCL, Sch Med, Auton Neurosci Ctr, Rowland Hill St, London NW3 2PF, England
[2] Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic, Australia
[3] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia
关键词
Pain; Infection; Cancer; CNS disorders; Cardiovascular; Airways; Diabetes; Kidney; Bladder; Liver; Gut; Immune cells; BRILLIANT BLUE G; TYPE-2; DIABETIC-RATS; P2X(7) RECEPTOR; PURINERGIC RECEPTORS; EXTRACELLULAR ATP; MOUSE MODEL; NLRP3; INFLAMMASOME; IN-VIVO; CELL INVASION; ANIMAL-MODEL;
D O I
10.1007/s11302-017-9593-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular C terminus. Low concentrations of ATP open cation channels sometimes leading to cell proliferation, whereas high concentrations of ATP open large pores that release inflammatory cytokines and can lead to apoptotic cell death. Since many diseases involve inflammation and immune responses, and the P2X7R regulates inflammation, there has been recent interest in the pathophysiological roles of P2X7R and the potential of P2X7R antagonists to treat a variety of diseases. These include neurodegenerative diseases, psychiatric disorders, epilepsy and a number of diseases of peripheral organs, including the cardiovascular, airways, kidney, liver, bladder, skin and musculoskeletal. The potential of P2X7R drugs to treat tumour progression is discussed.
引用
收藏
页码:1 / 18
页数:18
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