RHEUMATOID ARTHRITIS: Autoantibodies, citrullinated histones and initiation of synovitis

被引：5
|
作者：
Deane, Kevin D. [1 ]
机构：
[1] Univ Colorado Denver, Sch Med, Div Rheumatol, Aurora, CO 80045 USA
来源：
NATURE REVIEWS RHEUMATOLOGY | 2015年 / 11卷 / 12期
关键词：
ARTHRALGIA;
D O I：
10.1038/nrrheum.2015.134
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the development of rheumatoid arthritis, which factors govern the transition from systemic autoimmunity to synovitis? A study combining findings from human disease and animal models suggests that autoantibodies to neutrophil-derived citrullinated histone 2B are important for this transition; however, a 'second hit' involving intra-articular inflammation and citrullination could also be crucial to this process.
引用
收藏
页码：688 / 689
页数：2
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