Nerve growth factor and the skin

被引:0
|
作者
Pincelli, C [1 ]
Yaar, M [1 ]
机构
[1] BOSTON UNIV, SCH MED, DEPT DERMATOL, BOSTON, MA 02215 USA
关键词
nerve growth factor; skin;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Nerve growth factor (NGF) is a neurotrophic polypeptide required for the survival and differentiation of sensory and sympathetic neurons (1, 2). NGF belongs to a small family of structurally and functionally related proteins termed neurotrophins (NTs), which include brain-derived neurotrophic factor (BDNF) (3), NT-3 (4) and NT-4/5 (5). All neurotrophic molecules exert their effect by binding two classes of transmembrane receptors. A low affinity receptor of similar to 75 kD (p75) (6), and a high affinity, tyrosine kinase receptor, of similar to 140 kD that belongs to the trk family of receptors (7, 8).
引用
收藏
页码:73 / 76
页数:4
相关论文
共 50 条
  • [21] Nerve Growth Factor-Evoked Nociceptor Sensitization in Pig Skin In Vivo
    Rukwied, Roman
    Schley, Marcus
    Forsch, Elmar
    Obreja, Otilia
    Dusch, Martin
    Schmelz, Martin
    JOURNAL OF NEUROSCIENCE RESEARCH, 2010, 88 (09) : 2066 - 2072
  • [22] THE SYNTHESIS OF NERVE GROWTH-FACTOR (NGF) IN DEVELOPING SKIN IS INDEPENDENT OF INNERVATION
    ROHRER, H
    HEUMANN, R
    THOENEN, H
    DEVELOPMENTAL BIOLOGY, 1988, 128 (01) : 240 - 244
  • [23] Nerve growth factor, human skin ulcers and vascularization. Our experience
    Aloe, L
    NGF AND RELATED MOLECULES IN HEALTH AND DISEASE, 2004, 146 : 515 - 522
  • [24] NERVE GROWTH AND FACTOR LEVELS IN DEVELOPING RAT SKIN - UP-REGULATION FOLLOWING SKIN WOUNDING
    CONSTANTINOU, J
    REYNOLDS, ML
    WOOLF, CJ
    SAFIEHGARABEDIAN, B
    FITZGERALD, M
    NEUROREPORT, 1994, 5 (17) : 2281 - 2284
  • [25] CHARACTERISTICS OF THE NERVE GROWTH-FACTOR RECEPTORS AND A NERVE GROWTH-FACTOR RECEPTOR NERVE GROWTH-FACTOR COVALENT COMPLEX
    STACH, RW
    WAGNER, BJ
    ENNULAT, DJ
    PEREZPOLO, JR
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1985, 26 (1-2) : 87 - 94
  • [26] Nerve growth factor as an angiogenic factor
    Nico, Beatrice
    Mangieri, Domenica
    Benagiano, Vincenzo
    Crivellato, Enrico
    Ribatti, Domenico
    MICROVASCULAR RESEARCH, 2008, 75 (02) : 135 - 141
  • [28] NERVE GROWTH-FACTOR BINDING DOMAIN OF THE NERVE GROWTH-FACTOR RECEPTOR
    WELCHER, AA
    BITLER, CM
    RADEKE, MJ
    SHOOTER, EM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (01) : 159 - 163
  • [29] Expression of nerve growth factor, nerve growth factor receptor and neuromodulin in regenerating muscle
    Heub, D
    Ganzmann, E
    Schellmann, U
    BRAIN PATHOLOGY, 1997, 7 (04) : 1119 - 1119
  • [30] Validity of skin blot examination for albumin and nerve growth factor β to detect itching of the skin in Indonesian older adults
    Sari, Dianis Wulan
    Minematsu, Takeo
    Yoshida, Mikako
    Noguchi-Watanabe, Maiko
    Tomida, Sanai
    Kitamura, Aya
    Abe, Masatoshi
    Sanada, Hiromi
    JOURNAL OF TISSUE VIABILITY, 2021, 30 (01) : 42 - 50