1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase

被引：4
|
作者：
Machado, Luciana E. S. F. [1 ,3 ]
Page, Rebecca [2 ,3 ]
Peti, Wolfgang [1 ,3 ]
机构：
[1] Brown Univ, Dept Mol Pharmacol Physiol & Biotechnol, Providence, RI 02912 USA
[2] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA
[3] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA
来源：
BIOMOLECULAR NMR ASSIGNMENTS | 2018年 / 12卷 / 01期
关键词：
HePTP; Protein tyrosine phosphatase; Vanadate; Inhibition; Protein dynamics; Leukemia; PROTEIN; EXPRESSION; P38-ALPHA; HEPTP;
D O I：
10.1007/s12104-017-9770-7
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The sequence-specific backbone assignment of hematopoietic protein tyrosine phosphatase (HePTP; PTPN7) in presence of vanadate has been determined, based on triple-resonance experiments using uniformly [C-13,N-15]-labeled protein. These assignments facilitate further studies of HePTP in the presence of inhibitors to target leukemia and provide further insights into the function of protein tyrosine phosphatases.
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收藏
页码：5 / 9
页数：5
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