Optimized vector purification and delivery methods to achieve enhanced liver transduction by AAV vectors

被引：0
|
作者：
Ayuso, Eduard [1 ]
Montane, Joel [1 ]
Mingozzi, Federico [2 ]
Anguela, Xavier M. [1 ]
Leon, Xavier [1 ]
Mann, Christopher [1 ]
Callejas, David [1 ]
Jimenez, Veronica [1 ]
Tafuro, Sabrina [1 ]
Andaluz, Anna [3 ]
Garcia, Felix [3 ]
Zhou, Shangzhen [2 ]
Wright, Fraiser [2 ]
High, Katherine A. [2 ]
Bosch, Fatima [1 ]
机构：
[1] Univ Autonoma Barcelona, Ctr Anim Biotecnol & Gene Therapy, Bellaterra, Spain
[2] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA
[3] Univ Autonoma Barcelona, Dept Anim Med & Surg, Bellaterra, Spain
来源：
HUMAN GENE THERAPY | 2008年 / 19卷 / 10期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
引用
收藏
页码：1118 / 1119
页数：2
相关论文
共 50 条
  • [21] Chemically-Engineered AAV Vectors: How Chemistry Improves AAV Liver Gene Delivery
    Lalys, Pierre-Alban
    Bouzelha, Mohammed
    Pavageau, Karine
    Alvarez-Dorta, Dimitri
    Bourdon, Audrey
    Gouin, Sebastien
    Jaulin, Nicolas
    Guilbaud, Mickael
    Le Guiner, Caroline
    Adjali, Oumeya
    Deniaud, David
    Mevel, Mathieu
    MOLECULAR THERAPY, 2022, 30 (04) : 70 - 70
  • [22] Targeting Visceral Fat by Intraperitoneal Delivery of Novel AAV Serotype Vector Restricting Off-Target Transduction in Liver
    Huang, Wei
    Liu, Xianglan
    Queen, Nicholas J.
    Cao, Lei
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2017, 6 : 68 - 78
  • [23] Changing the Route of Administration to Improve Liver Transduction by Recombinant AAV-Based Vectors
    Zabaleta, Nerea
    Salas, David
    Majowicz, Anna
    Hernandez-Alcoceba, Ruben
    Sier-Ferreira, Valerie
    Prieto, Jesus
    Bilbao, Ignacio
    Gonzalez-Aseguinolaza, Gloria
    MOLECULAR THERAPY, 2016, 24 : S120 - S120
  • [24] Characterization of a novel AAV capsid with enhanced brain transduction following systemic delivery
    Glenn, J. D.
    Yost, S.
    Firnberg, E.
    Mercer, A.
    Liu, Y.
    Coruzzi, L.
    Danos, O.
    Bruder, J. T.
    Karumuthil-Melethil, S.
    HUMAN GENE THERAPY, 2019, 30 (11) : A22 - A22
  • [25] Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice
    Scallan, CD
    Jiang, HY
    Liu, TY
    Patarroyo-White, S
    Sommer, JM
    Zhou, SZ
    Couto, LB
    Pierce, GF
    BLOOD, 2006, 107 (05) : 1810 - 1817
  • [26] Development of Optimized AAV2 Vector Biosynthesis and Purification Processes To Support High Capacity Production of Clinical Vectors of High Purity and Potency
    Hauck, Bernd
    Bajaj, Jitin
    Joyce, Sonali
    Qu, Guang
    Zelenaia, Olga A.
    High, Katherine A.
    Wright, J. Fraser
    MOLECULAR THERAPY, 2006, 13 : S196 - S196
  • [27] Development of self-complimenentary AAV vectors with markedly enhanced hepatocyte transduction efficiency.
    Petras, O
    Liu, T
    Lyandres, J
    Davern, TJ
    HEPATOLOGY, 2002, 36 (04) : 245A - 245A
  • [28] Directed evoluton of AAV vector mutants for enhanced gene delivery.
    Schaffer, DV
    Maheshri, N
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U214 - U214
  • [29] Liver Transduction Efficacy with AAV Vectors in Juvenile UGT1A1-Deficient Mice
    Bortolussi, Giulia
    Collaud, Fanny
    Iaconcig, Alessandra
    Charles, Severine
    Sola, Marcelo Simon
    Ronzitti, Giuseppe
    Muro, Andres F.
    Mingozzi, Federico
    MOLECULAR THERAPY, 2017, 25 (05) : 190 - 191
  • [30] Systemic Delivery of Tyrosine-Mutant AAV Vectors Results in Robust Transduction of Neurons in Adult Mice
    Iida, Asako
    Takino, Naomi
    Miyauchi, Hitomi
    Shimazaki, Kuniko
    Muramatsu, Shin-ichi
    BIOMED RESEARCH INTERNATIONAL, 2013, 2013
12345