Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

被引：157
|
作者：
Vennin, Claire [1 ,2 ,3 ]
Murphy, Kendelle J. [1 ,2 ,3 ]
Morton, Jennifer P. [4 ]
Cox, Thomas R. [1 ,2 ,3 ]
Pajic, Marina [1 ,2 ,3 ]
Timpson, Paul [1 ,2 ,3 ]
机构：
[1] Garvan Inst Med Res, Sydney, NSW, Australia
[2] Kinghorn Canc Ctr, Sydney, NSW, Australia
[3] Univ New South Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia
[4] Beatson Inst Canc Res, Canc Res UK, Glasgow, Lanark, Scotland
来源：
GASTROENTEROLOGY | 2018年 / 154卷 / 04期
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
Pancreatic Cancer; Stromal Remodeling; Invasion; Metastasis; Diagnostic Tool; Patient-Derived Models; DUCTAL ADENOCARCINOMA; THERAPEUTIC RESPONSE; TISSUE HOMEOSTASIS; HIGH-THROUGHPUT; CELL DORMANCY; MOUSE MODELS; T-CELLS; INHIBITION; FIBROBLASTS; PATIENT;
D O I：
10.1053/j.gastro.2017.11.280
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.
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页码：820 / 838
页数：19
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