An efficient synthesis of 3,4-dihydorpymidine(1H)-(thio)-ones catalyzed by novel SO3H-functionalized ionic liquids under ultrasound irradiation and solvent free conditions

被引：2
|
作者：
Li, BaiLin [1 ]
Ge, ChangHua [1 ]
Ying, An Guo [1 ]
机构：
[1] Taizhou Coll, Dept Pharmaceut & Chem Engn, Linhai 317000, Zhejiang, Peoples R China
来源：
ADVANCED RESEARCH ON MATERIAL ENGINEERING, CHEMISTRY, BIOINFORMATICS II | 2012年 / 531卷
关键词：
Biginelli reaction; Dihydropyrimidinone; Ionic liquid; Ultrasound irradiation; ONE-POT SYNTHESIS; CALCIUM-CHANNEL BLOCKERS; BIGINELLI REACTION; ACID-ESTERS; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; ESTERIFICATION; CONDENSATION; GREEN;
D O I：
10.4028/www.scientific.net/AMR.531.428
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Novel SO3H-functionalized ionic liquids were successfully applied as catalysts for the one-pot three component Biginelli condensation under ultrasound irradiation without solvent. Various types of 3,4-dihydorpymidine(1H)-(thio)-ones were provided in 84-98% yields and conveniently separated from the reaction mixture by filtration, the dissolved catalyst could be reused with simple treatment. This novel synthetic method is especially favoured because it provides a synergy between ionic liquids and ultrasound irradiation which offers the advantages of high yields, short reaction times, simplicity, and easy workup compared to the conventional methods reported in the literature..
引用
收藏
页码：428 / 431
页数：4
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