Chick Chorioallantoic Membrane as an In Situ Biological Membrane for Pharmaceutical Formulation Development: A Review

被引：10
|
作者：
Saw, Constance L. L. [1 ]
Heng, Paul W. S. [1 ]
Liew, Celine V. [1 ]
机构：
[1] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2008年 / 34卷 / 11期
关键词：
Draize test; chick chorioallantoic membrane; formulation development; drug delivery; transport study; permeation;
D O I：
10.1080/03639040801974295
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The use of animals in research has always been a debatable issue. Over the past few decades, efforts have been made to reduce, replace, and refine experiments for ethical use of experimental animals. The use of chick chorioallantoic membrane (CAM) was one of the proposed alternatives to the Draize rabbit ocular irritation test with several advantages including simplicity, rapidity, sensitivity, ease of performance, and cost-effectiveness. The recent use of CAM in the development of pharmaceuticals and testing models to mimic human tissue, including drug transport across CAM, will be discussed in this review.
引用
收藏
页码：1168 / 1177
页数：10
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