Spray drying and vaccine stabilization

被引：0
|
作者：
McAdams, David [1 ]
Chen, Dexiang [1 ]
Kristensen, Debra [1 ]
机构：
[1] PATH, Seattle, WA 98121 USA
来源：
EXPERT REVIEW OF VACCINES | 2012年 / 11卷 / 10期
基金：
比尔及梅琳达.盖茨基金会;
关键词：
dry vaccine formulation; inhaled particles; lyophilization; mucosal delivery; particle engineering; spray drying; stabilization; thermostability; POWDER FORMULATION; VIRUS-VACCINE; IMMUNIZATION; MICROPARTICLES; STABILITY; ANTIGEN;
D O I：
10.1586/ERV.12.101
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Research on spray drying as a processing method to improve vaccine stabilization and to enable novel routes of vaccine delivery has produced promising results; however, the method has yet to be adopted for the manufacture of vaccine products by the pharmaceutical industry. This article reviews the status of spray-drying technology and discusses barriers and opportunities for its future application to vaccines.
引用
收藏
页码：1211 / 1219
页数：9
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