Induced Pluripotent Stem Cell-Derived Cardiomyocytes A Versatile Tool for Arrhythmia Research

被引：39

作者：

Sinnecker, Daniel ^{[1
]}

Goedel, Alexander ^{[1
]}

Laugwitz, Karl-Ludwig ^{[1
]}

Moretti, Alessandra ^{[1
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Med Klin 1, D-81675 Munich, Germany

来源：

CIRCULATION RESEARCH | 2013年 / 112卷 / 06期

基金：

欧洲研究理事会;

关键词：

catecholaminergic polymorphic ventricular tachycardia; disease modeling; long-QT syndrome; reprogramming; LONG QT SYNDROME; BRUGADA-SYNDROME; FUNCTIONAL CARDIOMYOCYTES; DIFFERENTIATION; FIBROBLASTS; MODELS; SELECTION; MYOCYTES; DISEASE; REPAIR;

D O I：

10.1161/CIRCRESAHA.112.268623

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Induced pluripotent stem cells offer the possibility to generate patient-specific stem cell lines from individuals affected by inherited disorders. Cardiomyocytes differentiated from such patient-specific induced pluripotent stem cells lines have been used to study the pathophysiology of arrhythmogenic heart diseases, such as the long-QT syndrome or catecholaminergic polymorphic ventricular tachycardia. Testing for unwanted drug side effects or tailoring medical treatment to the specific needs of individual patients with arrhythmogenic disorders may become future applications of this emerging technology. (Circ Res. 2013;112:961-968.)

引用

页码：961 / 968

页数：8

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