A novel Ag/AgO/carboxymethyl chitosan bacteriostatic hydrogel for drug delivery

被引：12
|
作者：
Xu, Yanqin [1 ]
Liu, Jie [1 ]
Guan, Shumin [1 ]
Dong, Aotong [2 ,3 ]
Cao, Yuan [1 ]
Chen, Changguo [1 ]
机构：
[1] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China
[2] Chongqing Univ, Sch Journalism & Commun, Chongqing 401331, Peoples R China
[3] Chongqing Univ, Sch Big Data & Software Engn, Chongqing 401331, Peoples R China
来源：
MATERIALS RESEARCH EXPRESS | 2020年 / 7卷 / 08期
关键词：
silver; silver oxide; carboxymethyl chitosan; pH-sensitive hydrogel; antibacterial property; ORTHO ESTER LINKAGE; CARBOXYMETHYL CHITOSAN; SMART HYDROGEL; IN-VITRO; DEGRADATION; NANOPARTICLES; MICROSPHERES;
D O I：
10.1088/2053-1591/aba5cd
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
pH-sensitive Ag/AgO/carboxymethyl chitosan (CMCS) bacteriostatic hydrogels and Ag/AgO/CMCS/Aspirin (ASP) carrier hydrogels were prepared by Ag/AgOin situprecipitation method, and the effects of swelling, degradation, drug release and antibacterial properties of hydrogels were studied. The network of Ag/AgO/CMCS/ASP drug-loaded gels produced was mainly cross-linking by hydrogen bonding and intermolecular forces, and the cross-linking silver was mainly present in the elemental Ag and Ag(2+)states. Under the condition of buffer solution pH = 7.4, the cumulative release amount of Ag/AgO/CMCS/ASP drug-loaded gel was 75.20% within 12 h, and the inhibition rate of Gram-negativeEscherichia coli(E. coli) reached the maximum of 92.32%, which had broad application prospects in the medical field.
引用
收藏
页数：12
相关论文
共 50 条
  • [41] Synthesis and characterization of carboxymethyl chitosan hydrogel: Application as site specific delivery for lercanidipine hydrochloride
    Vaghani, Subhash S.
    Patel, Madhabhai M.
    Satish, C. S.
    Patel, Kandarp M.
    Jivani, N. P.
    BULLETIN OF MATERIALS SCIENCE, 2012, 35 (07) : 1133 - 1142
  • [42] Synthesis and Characterization of Carboxymethyl Chitosan Hydrogel: Application as pH-Sensitive Delivery for Nateglinide
    Vaghani, Subhash S.
    Patel, Madhabhai M.
    Satish, C. S.
    Patel, Kandarp M.
    Jivani, Nurudin P.
    CURRENT DRUG DELIVERY, 2012, 9 (06) : 628 - 636
  • [43] Synthesis and characterization of carboxymethyl chitosan hydrogel: Application as site specific delivery for lercanidipine hydrochloride
    SUBHASH S VAGHANI
    MADHABHAI M PATEL
    C S SATISH
    KANDARP M PATEL
    N P JIVANI
    Bulletin of Materials Science, 2012, 35 : 1133 - 1142
  • [44] Green fabrication, characterization and antimicrobial activities of AgO/Ag/ carboxymethyl chitosan- graphene oxide films
    Li, Chen
    Wang, Ke
    Li, Fayong
    Xie, Dong
    ARABIAN JOURNAL OF CHEMISTRY, 2024, 17 (01)
  • [45] Dual-crosslinked alginate/carboxymethyl chitosan hydrogel containing in situ synthesized calcium phosphate particles for drug delivery application
    Potiwiput, Sugunya
    Tan, Huaping
    Yuan, Guoliang
    Li, Shengke
    Zhou, Tianle
    Li, Jianliang
    Jia, Yang
    Xiong, Dangsheng
    Hu, Xiaohong
    Ling, Zhonghua
    Chen, Yong
    MATERIALS CHEMISTRY AND PHYSICS, 2020, 241
  • [46] Injectable mesquite gum and carboxymethyl chitosan hydrogel using schiff base crosslinks: a versatile platform for drug delivery in wound care
    Kumar, Jitendra
    Purwar, Roli
    MACROMOLECULAR RESEARCH, 2024, 32 (12) : 1237 - 1254
  • [47] A Novel Composite Hydrogel Based on Chitosan and Inorganic Phosphate for Local Drug Delivery of Camptothecin Nanocolloids
    Li, Xingyi
    Kong, Xiangye
    Zhang, Juan
    Wang, Yingjing
    Wang, Yujun
    Shi, Shuai
    Guo, Gang
    Luo, Feng
    Zhao, Xia
    Wei, Yuquan
    Qian, Zhiyong
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 100 (01) : 232 - 241
  • [48] Synthesis, characterizations, and release mechanisms of carboxymethyl chitosan-graphene oxide-gelatin composite hydrogel for controlled delivery of drug
    Li, Chen
    Li, Fayong
    Wang, Ke
    Wang, Qing
    Liu, Hailu
    Sun, Xiaoyan
    Xie, Dong
    INORGANIC CHEMISTRY COMMUNICATIONS, 2023, 155
  • [49] Preparation and application of a novel pH-responsive linalool carboxymethyl chitosan hydrogel
    An, Yuanbiao
    Zhai, Rui
    Chen, Jinni
    Xie, Peng
    JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, 2023, 60 (05): : 336 - 345
  • [50] Thermal sensitive Poloxamer/Chitosan hydrogel for drug delivery in vagina
    Wu, Qian
    Li, Liang
    MATERIALS RESEARCH EXPRESS, 2020, 7 (10)
12345