Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

被引：34

作者：

Maoka, Takashi ^{[1
]}

Yasui, Hiroyuki ^{[2
]}

Ohmori, Aya ^{[2
]}

Tokuda, Harukuni ^{[3
]}

Suzuki, Nobutaka ^{[3
]}

Osawa, Ayako ^{[4
]}

Shindo, Kazutoshi ^{[4
]}

Ishibashi, Takashi ^{[5
]}

机构：

[1] Res Inst Prod Dev, Sakyo Ku, Kyoto 6060805, Japan

[2] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Div Analyt & Phys Chem, Yamashina Ku, Kyoto 6078414, Japan

[3] Kanazawa Univ, Dept Complementary & Alternat Med, Clin R&D, Grad Sch Med Sci, Kanazawa, Ishikawa 9208640, Japan

[4] Japan Womens Univ, Dept Food & Nutr, Bunkyo Ku, Tokyo 1128681, Japan

[5] JX Nippon Oil & Energy Corp, Biotechnol Business Sect, Dept Life Sci, Toda, Saitama 3358502, Japan

来源：

JOURNAL OF OLEO SCIENCE | 2013年 / 62卷 / 03期

关键词：

adonirubin; adonixanthin; anti-oxidative activity; anti-tumor-promoting activity; anti-carcinogenic activity; NATURALLY-OCCURRING XANTHOPHYLLS; ASTAXANTHIN; CAROTENOIDS; CARCINOGENESIS; CHEMOPREVENTION;

D O I：

10.5650/jos.62.181

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from beta-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.

引用

页码：181 / 186

页数：6

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