Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease

被引：95

作者：

Filali, M. ^{[1
,2
]}

Lalonde, R. ^{[3
,4
]}

Rivest, S. ^{[1
,2
]}

机构：

[1] CHU Laval, Ctr Rech, CHUQ, Mol Endocrinol Lab, Quebec City, PQ G1V 4G2, Canada

[2] Univ Laval, Dept Anat & Physiol, Quebec City, PQ, Canada

[3] Ctr Hosp Univ Montreal St Luc, Unite Rech Sci Neurol, Montreal, PQ, Canada

[4] Univ Rouen, Fac Sci, Rouen, France

来源：

GENES BRAIN AND BEHAVIOR | 2009年 / 8卷 / 02期

关键词：

Alzheimer's disease; APPswe; PS1; depressive-like behavior; forced swim test; nesting behavior; social disinhibition; T-water maze; AMYLOID PRECURSOR PROTEIN; DOUBLE TRANSGENIC MICE; MOUSE MODEL; MEMORY; BETA; DEPOSITION; DEFICITS; BRAIN; PRESENILIN-1; DYSFUNCTION;

D O I：

10.1111/j.1601-183X.2008.00453.x

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non-transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression-like behavior in an Alzheimer's disease model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left-right discrimination learning, concordant with previous findings in other Alzheimer-like models.

引用

页码：143 / 148

页数：6

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