RECALCITRANT MACULAR EDEMA AFTER INTRAVITREAL BEVACIZUMAB IS RESPONSIVE TO AN INTRAVITREAL DEXAMETHASONE IMPLANT IN RETINAL VEIN OCCLUSION

被引：21
|
作者：
Sharareh, Behnam [1 ,2 ]
Gallemore, Ron [1 ]
Taban, Mehran [1 ]
Onishi, Spencer [1 ]
Wallsh, Josh [1 ]
机构：
[1] Retina Macula Inst, Torrance, CA 90503 USA
[2] Univ Calif Irvine, Sch Med, Irvine, CA 92717 USA
来源：
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2013年 / 33卷 / 06期
关键词：
retinal vein occlusion; Ozurdex; macular edema; Avastin; bevacizumab; dexamethasone; resistance; anti-VEGF; SECONDARY; THERAPY; AVASTIN; EYES;
D O I：
10.1097/IAE.0b013e31827c53a0
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To test the efficacy of an intravitreal dexamethasone implant in patients with recalcitrant macular edema secondary to retinal vein occlusion. Methods: A retrospective chart review was performed for 18 patients with retinal vein occlusion who received multiple bevacizumab intravitreal injections before treatment with an intravitreal dexamethasone implant. Results: Two subgroups of bevacizumab-resistant patients were identified. Both subgroups responded to subsequent treatment with an intravitreal dexamethasone implant with an average reduction in central foveal thickness of 146.8 +/- 33.65 mu m. A visual acuity improvement of 0.26 +/- 0.07 (logarithm of minimal angle of resolution) was also noted. Intraocular pressure increased by an average of 3.33 +/- 0.66 mmHg and was managed by 1.0 +/- 0.5 topical drops. Conclusion: A subset of patients do not have resolution of macular edema after treatment with intravitreal bevacizumab. Such patients may respond to treatment with an intravitreal dexamethasone implant.
引用
收藏
页码：1227 / 1231
页数：5
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