Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC)

被引:17
|
作者
Rosenhall, Ulf [1 ,2 ]
Skoog, Bjorn [3 ]
Muhr, Per [1 ,4 ]
机构
[1] Reg Vastra Gotaland, Audiol Dept, Habilitering & Halsa, Gothenburg, Sweden
[2] Univ Gothenburg, Inst Neurosci & Physiol, Div Audiol, Dept Hlth & Rehabil, Box 455, SE-404530 Gothenburg, Sweden
[3] Armed Forces Ctr Def Med, Gothenburg, Sweden
[4] Karolinska Inst, Unit Audiol Intervent & Technol, Dept Clin Sci, Stockholm, Sweden
关键词
Acoustic trauma; antioxidant (AO); noise-induced hearing loss (NIHL); permanent threshold shift (PTS); relative risk (RR); Swedish Armed Forces (SAF); temporary threshold shift (TTS); INDUCED HEARING-LOSS; TEMPORARY THRESHOLD SHIFT; NOISE; ACETYLCYSTEINE; PREVENTION; PROTECTION; EXPOSURES; EFFICACY;
D O I
10.1080/14992027.2018.1543961
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Objective: To study if the antioxidant (AO) N-Acetyl-L-cysteine (NAC) reduces the risk of hearing loss after acoustic accidents in humans. Design: A retrospective, observational study. Study sample: Personnel of the Swedish Armed Forces (SAF) exposed to military acoustic accidents during a 5 year period. Included in the study were 221 cases (mean age: 22.9 years). Most of the exposures, 84%, were weapon related. NAC (400 mg) was given directly after the accident in 146 cases; 75 had not received NAC. Results: The prevalence of hearing thresholds >= 25 dB HL, and the incidence of threshold shifts >= 10 dB, was lower in the NAC group than in the non-NAC group directly after the noise exposure. The deterioration was temporary and not discernable a long time after the accident. The difference was most pronounced in the right ear. The risk reduction to get a temporary hearing loss (TTS), affecting one or both ears was 39% (significant) in the NAC group. Conclusions: The study has demonstrated a significant reduction of the incidence of TTS by the use of NAC. Since cases of both permanent hearing loss (PTS) and noise-induced tinnitus are recruited from cases with TTS, the demonstrated risk reduction indicates a positive effect of NAC.
引用
收藏
页码:151 / 157
页数:7
相关论文
共 50 条
  • [21] Oral N-acetyl-L-cysteine is a safe and effective precursor of cysteine
    Dilger, R. N.
    Baker, D. H.
    JOURNAL OF ANIMAL SCIENCE, 2007, 85 (07) : 1712 - 1718
  • [22] LIQUEFACTION OF SPUTUM BY N-ACETYL-L-CYSTEINE AND DITHIOTHREITOL
    MACDONALD, J
    CANADIAN JOURNAL OF MEDICAL TECHNOLOGY, 1972, 34 (06): : 204 - +
  • [23] Correction to: The Potential of N‑Acetyl‑L‑Cysteine (NAC) in the Treatment of Psychiatric Disorders
    Richard C. J. Bradlow
    Michael Berk
    Peter W. Kalivas
    Sudie E. Back
    Richard A. Kanaan
    CNS Drugs, 2022, 36 : 553 - 553
  • [24] Niosomes loading N-acetyl-L-cysteine for cancer treatment in vivo study
    Mohamad, Ebtesam A.
    Ali, Abeer A.
    Sharaky, Marwa
    El-Gebaly, Reem H.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 (06) : 4339 - 4353
  • [25] Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries
    Yang, Wei Ping
    Hu, Bo Hua
    Chen, Guang Di
    Bielefeld, Eric C.
    Henderson, Donald
    ACTA OTO-LARYNGOLOGICA, 2009, 129 (10) : 1036 - 1043
  • [26] N-Acetyl-L-Cysteine (NAC) Blunts Axitinib-Related Adverse Effects in Preclinical Models of Glioblastoma
    Formato, Alessia
    Salbini, Maria
    Orecchini, Elisa
    Pellegrini, Manuela
    Buccarelli, Mariachiara
    Vitiani, Lucia Ricci
    Giannetti, Stefano
    Pallini, Roberto
    D'Alessandris, Quintino Giorgio
    Lauretti, Liverana
    Martini, Maurizio
    De Falco, Valentina
    Levi, Andrea
    Falchetti, Maria Laura
    Mongiardi, Maria Patrizia
    CANCER MEDICINE, 2024, 13 (19):
  • [27] Protective effect of N-Acetyl-L-Cysteine (NAC) on endosulfan-induced liver and kidney toxicity in rats
    Beceren, Ayfer
    Sehirli, Ahmet Ozer
    Omurtag, Gulden Zehra
    Arbak, Serap
    Turan, Pinar
    Sener, Goksel
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (07): : 10031 - 10039
  • [28] In vitro assessment of the neurotoxic and neuroprotective effects of N-acetyl-L-cysteine (NAC) on the rat sciatic nerve fibers
    Moschou, Magdalini
    Kosmidis, Efstratios K.
    Kaloylanni, Martha
    Geronikaki, A.
    Dabarakis, N.
    Theophilidis, George
    TOXICOLOGY IN VITRO, 2008, 22 (01) : 267 - 274
  • [29] COMPARISON OF N-ACETYL-L-CYSTEINE AND L-CYSTEINE IN RESPECT TO THEIR TRANSMEMBRANE FLUXES
    Yildiz, D.
    Arik, M.
    Cakir, Y.
    Civi, Z.
    BIOLOGICHESKIE MEMBRANY, 2009, 26 (02): : 143 - 148
  • [30] Comparison of N-acetyl-L-cysteine and L-cysteine in respect to their transmembrane fluxes
    Yildiz D.
    Arik M.
    Cakir Y.
    Civi Z.
    Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2009, 3 (2) : 157 - 162