Cardiac Grk2 Blockade Augments β2-Adrenergic Receptor-Dependent Contractility and Survival Post Myocardial Infarction

被引：0
|
作者：
Lymperopoulos, Anastasios [1 ]
Rengo, Giuseppe [2 ]
Gao, Erhe [3 ]
Koch, Walter J. [3 ]
机构：
[1] Nova SE Univ, Ft Lauderdale, FL 33314 USA
[2] Univ Naples Federico II, Naples, Italy
[3] Temple Univ, Philadelphia, PA 19122 USA
来源：
CIRCULATION RESEARCH | 2012年 / 111卷 / 04期
关键词：
Receptors; Signal transduction; Myocardial infarction;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
103
引用
收藏
页数：1
相关论文
共 50 条
  • [31] Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling
    Jean-Charles, Pierre-Yves
    Yu, Samuel Mon-Wei
    Abraham, Dennis
    Kommaddi, Reddy Peera
    Mao, Lan
    Strachan, Ryan T.
    Zhang, Zhu-Shan
    Bowles, Dawn E.
    Brian, Leigh
    Stiber, Jonathan A.
    Jones, Stephen N.
    Koch, Walter J.
    Rockman, Howard A.
    Shenoy, Sudha K.
    JCI INSIGHT, 2017, 2 (17):
  • [32] GRK2 downstream aldosterone and mineralocorticoid receptor system induces cardiac insulin-resistance and β-adrenergic dysfunction
    Marzano, Federica
    Liccardo, Daniela
    Koch, Walter J.
    Rengo, Giuseppe
    Cannavo, Alessandro
    VASCULAR PHARMACOLOGY, 2020, 132
  • [33] Deletion of Osteopontin Enhances β2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes
    Pollard, Celina M.
    Desimine, Victoria L.
    Wertz, Shelby L.
    Perez, Arianna
    Parker, Barbara M.
    Maning, Jennifer
    McCrink, Katie A.
    Shehadeh, Lina A.
    Lymperopoulos, Anastasios
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (06)
  • [34] RKIP corrects impaired beta (2)-adrenergic receptor vasodilatation in hypertension by downregulation of GRK2
    Gui, Ya-jun
    Liao, Cai-xiu
    Liu, Qiong
    Guo, Yuan
    Xu, Dan-yan
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016, 207 : 359 - 360
  • [35] Real-time measurements of the interaction of GRK2 with the α2A-adrenergic receptor and Gβγ
    Krasel, C.
    Prokopets, O.
    Zindel, D.
    Buenemann, M.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2013, 386 : S44 - S44
  • [36] Membrane-permeable tastants amplify β2-adrenergic receptor signaling and delay receptor desensitization via intracellular inhibition of GRK2's kinase activity
    Malach, Einav
    Shaul, Merav E.
    Peri, Irena
    Huang, Liquan
    Spielman, Andrew I.
    Seger, Rony
    Naim, Michael
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2015, 1850 (07): : 1375 - 1388
  • [37] PI3KC2α controls cardiac contractility through regulation of β2-adrenergic receptor recycling
    Cnudde, Sophie
    Brand, Theresa
    Fender, Julia
    Prever, Lorenzo
    Murabito, Alessandra
    Russo, Michele
    Logrand, Federica
    Gulluni, Federico
    Lorenz, Kristina
    Hirsch, Emilio
    Ghigo, Alessandra
    VASCULAR PHARMACOLOGY, 2024, 155 : 107313
  • [38] Osteopontin promotes G protein-coupled receptor kinase (GRK)-2-dependent desensitization of cardiac β2-adrenergic receptor anti-fibrotic signaling
    Lymperopoulos, Anastasios
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 385
  • [39] Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy
    Cannavo, Alessandro
    Liccardo, Daniela
    Koch, Walter J.
    FRONTIERS IN PHYSIOLOGY, 2013, 4
  • [40] Phosphorylation of the β2-Adrenergic receptor in plasma membranes by intrinsic GRK5
    Tran, Tuan M.
    Jorgensen, Rasmus
    Clark, Richard B.
    BIOCHEMISTRY, 2007, 46 (50) : 14438 - 14449
12345