Antimalarial activity of methylpiperazinyl-substituted benzophenone-based farnesyltransferase inhibitors

被引:0
|
作者
Kettler, K
Wiesner, J
Ortmann, R
Dahse, HM
Jomaa, H
Schlitzer, M
机构
[1] Univ Munich, Dept Pharm, Zentrum Pharmaforsch, D-81377 Munich, Germany
[2] Univ Giessen, Inst Biomed, Hans Knoll Inst Naturstoff Forsch EV, Jena, Germany
来源
PHARMAZIE | 2006年 / 61卷 / 01期
关键词
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:63 / 65
页数:3
相关论文
共 50 条
  • [21] Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity
    Li, Q
    Li, TM
    Woods, KW
    Gu, WZ
    Cohen, J
    Stoll, VS
    Galicia, T
    Hutchins, C
    Frost, D
    Rosenberg, SH
    Sham, HL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (11) : 2918 - 2922
  • [22] Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
    Kokkonda, Sreekanth
    El Mazouni, Farah
    White, Karen L.
    White, John
    Shackleford, David M.
    Jose Lafuente-Monasterio, Maria
    Rowland, Paul
    Manjalanagara, Krishne
    Joseph, Jayan T.
    Garcia-Perez, Adolfo
    Fernandez, Jorge
    Javier Gamo, Francisco
    Waterson, David
    Burrows, Jeremy N.
    Palmer, Michael J.
    Charman, Susan A.
    Rathod, Pradipsinh K.
    Phillips, Margaret A.
    ACS OMEGA, 2018, 3 (08): : 9227 - 9240
  • [23] Synthesis and antimalarial activity of quinoline-substituted furanone derivatives and their identification as selective falcipain-2 inhibitors
    Mymoona Akhter
    Rikta Saha
    Omprakash Tanwar
    Md. Mumtaz Alam
    M. S. Zaman
    Medicinal Chemistry Research, 2015, 24 : 879 - 890
  • [24] Synthesis and antimalarial activity of quinoline-substituted furanone derivatives and their identification as selective falcipain-2 inhibitors
    Akhter, Mymoona
    Saha, Rikta
    Tanwar, Omprakash
    Alam, Md. Mumtaz
    Zaman, M. S.
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (02) : 879 - 890
  • [25] Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors
    Dow, Geoffrey S.
    Chen, Yufeng
    Andrews, Katherine T.
    Caridha, Diana
    Gerena, Lucia
    Gettayacamin, Montip
    Johnson, Jacob
    Li, Qigui
    Melendez, Victor
    Obaldia, Nicanor, III
    Tran, Thanh N.
    Kozikowski, Alan P.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (10) : 3467 - 3477
  • [26] Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: Substrate-based design, conformational constraint and biological activity
    Dinsmore, CJ
    Bell, IM
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (10) : 1075 - 1093
  • [27] Identification of novel PfDHODH inhibitors as antimalarial agents via pharmacophore-based virtual screening followed by molecular docking and in vivo antimalarial activity
    Vyas, V. K.
    Qureshi, G.
    Ghate, M.
    Patel, H.
    Dalai, S.
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2016, 27 (06) : 427 - 440
  • [28] Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors
    Flipo, M
    Florent, I
    Grellier, P
    Sergheraert, C
    Deprez-Poulain, R
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (16) : 2659 - 2662
  • [29] Tenellones A and B from a Diaporthe sp.:: Two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity
    Zhang, CW
    Ondeyka, JG
    Herath, KB
    Guan, ZQ
    Collado, J
    Platas, G
    Pelaez, F
    Leavitt, PS
    Gurnett, A
    Nare, B
    Liberator, P
    Singh, SB
    JOURNAL OF NATURAL PRODUCTS, 2005, 68 (04): : 611 - 613
  • [30] Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors
    Gundersen, E
    Fan, K
    Haas, K
    Huryn, D
    Jacobsen, JS
    Kreft, A
    Martone, R
    Mayer, S
    Sonnenberg-Reines, J
    Sun, SC
    Zhou, H
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (07) : 1891 - 1894