Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

被引：36
|
作者：
Piacham, T
Isarankura-Na-Ayudhya, C
Nantasenamat, C
Yainoy, S
Ye, L
Bülow, L
Prachayasittikul, V [1 ]
机构：
[1] Mahidol Univ, Fac Med Technol, Dept Clin Microbiol, Bangkok 10700, Thailand
[2] Lund Univ, Ctr Chem, S-22100 Lund, Sweden
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 341卷 / 04期
关键词：
antibiotic; bacitracin; superoxide dismutase; SOD; SOD mimic; molecular modeling;
D O I：
10.1016/j.bbrc.2006.01.045
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：925 / 930
页数：6
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