TLR2 inhibition reprograms the tumor microenvironment and delays progression of recurrent ovarian cancer in vivo

被引:0
|
作者
Alvero, A. [1 ]
Pitruzzello, M. [1 ]
Keogh, B. [2 ]
Mcguirk, P. [2 ]
Reilly, M. [2 ]
Mor, G. [1 ]
机构
[1] Yale Univ, Ob Gyn, New Haven, CT USA
[2] Opsona Therapeut Ltd, Vivo Pharmacol, Dublin, Ireland
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
320 (PB-08
引用
收藏
页码:E107 / E107
页数:1
相关论文
共 50 条
  • [41] IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer
    Caetano, Mauricio S.
    Zhang, Huiyuan
    Cumpian, Amber M.
    Gong, Lei
    Unver, Nese
    Ostrin, Edwin J.
    Daliri, Soudabeh
    Chang, Seon Hee
    Ochoa, Cesar E.
    Hanash, Samir
    Behrens, Carmen
    Wistuba, Ignacio I.
    Sternberg, Cinthya
    Kadara, Humam
    Ferreira, Carlos Gil
    Watowich, Stephanie S.
    Moghaddam, Seyed Javad
    CANCER RESEARCH, 2016, 76 (11) : 3189 - 3199
  • [42] Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design
    Li, Yan-Ruide
    Ochoa, Christopher J.
    Zhu, Yichen
    Kramer, Adam
    Wilson, Matthew
    Fang, Ying
    Chen, Yuning
    Singh, Tanya
    Di Bernardo, Gabriella
    Zhu, Enbo
    Lee, Derek
    Moatamed, Neda A.
    Bando, Joanne
    Zhou, Jin J.
    Memarzadeh, Sanaz
    Yang, Lili
    ISCIENCE, 2023, 26 (10)
  • [43] RAD001 (everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer
    Mabuchi, Seiji
    Altomare, Deborah A.
    Connolly, Denise C.
    Klein-Szanto, Andres
    Litwin, Samuel
    Hoelzle, Matthew K.
    Hensley, Harvey H.
    Hamilton, Thomas C.
    Testa, Joseph R.
    CANCER RESEARCH, 2007, 67 (06) : 2408 - 2413
  • [44] Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer
    Wick, Darin A.
    Webb, John R.
    Nielsen, Julie S.
    Martin, Spencer D.
    Kroeger, David R.
    Milne, Katy
    Castellarin, Mauro
    Twumasi-Boateng, Kwame
    Watson, Peter H.
    Holt, Rob A.
    Nelson, Brad H.
    CLINICAL CANCER RESEARCH, 2014, 20 (05) : 1125 - 1134
  • [45] TLR2 inhibition with OPN-305 increases the efficacy of gemcitabine in a murine model of pancreatic cancer
    Keogh, B.
    McGuirk, P.
    Hagemann, T.
    IMMUNOLOGY, 2013, 140 : 74 - 74
  • [46] TLR2 inhibition for cancer therapy, a novel approach with Tomaralimab a humanised IgG4 antibody
    Keogh, B.
    Mcguirk, P.
    Kearney, T.
    Alvero, A.
    Mor, G.
    Gupta, S.
    Garcia-Manero, G.
    Wei, Y.
    Jenkins, B.
    Miller, R.
    Reilly, M.
    EUROPEAN JOURNAL OF CANCER, 2018, 103 : E7 - E7
  • [47] Fibroblast-specific IL1 receptor inhibition reprograms the inflammatory stroma to overcome the immunosuppressive tumor microenvironment in pancreatic cancer
    Acevedo, Camille
    Singh, Samara
    Dosch, Austin
    Box, Edmond W.
    Silva, Iago C.
    Bianchi, Anna
    Mehra, Siddharth
    Amirian, Haleh
    Adams, Andrew
    Nagathihalli, Nagaraj
    Datta, Jashodeep
    Merchant, Nipun B.
    CANCER RESEARCH, 2024, 84 (17)
  • [48] Activation of TLR2 and TLR5 did not affect tumor progression of an oral squamous cell carcinoma, YD-10B cells
    Park, Jong-Hwan
    Yoon, Hyo-Eun
    Jeon, Do-In
    Ahn, Sang-Gun
    Yoon, Jung-Hoon
    JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2010, 39 (10) : 781 - 785
  • [49] Inhibition of Acetylcholine Expression in the Tumor Microenvironment by Mustard Oil: A Potential Strategy to Retard Colon Cancer Progression
    Chen, Hu
    Wang, Na
    Wei, Shunli
    Xu, Xinjian
    Wu, Chunxiao
    Liu, Shugang
    ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE, 2023, 29 (08) : 246 - 251
  • [50] The inhibition of leptin receptor impairs macrophage recruitment in the tumor microenvironment blocking breast cancer growth and progression
    Gelsomino, Luca
    Panza, Salvatore
    Augimeri, Giuseppina
    Naimo, Giuseppina Daniela
    Malivindi, Rocco
    La Camera, Giusi
    Paoli, Alessandro
    Giordano, Cinzia
    Barone, Ines
    Mauro, Loredana
    Bonofiglio, Daniela
    Catalano, Stefania
    Ando, Sebastiano
    CANCER RESEARCH, 2020, 80 (04)