Sleep-dependent synaptic plasticity is crucial for optimal cognition. However, establishing the direction of synaptic plasticity during sleep has been particularly challenging since data in support of both synaptic potentiation and depotentiation have been reported. This review focuses on structural synaptic plasticity across sleep and wake and summarizes recent developments in the use of 3-dimensional electron microscopy as applied to this field.
机构:
Univ Penn, Perelman Sch Med, Dept Neurosci, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA
Frank, Marcos G.
Cantera, Rafael
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机构:
Stockholm Univ, Dept Zool, S-10691 Stockholm, Sweden
Inst Invest Biol Clemente Estable, Montevideo, UruguayUniv Penn, Perelman Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA