Computing the threshold of the influence of intercellular nanotubes on cell-to-cell communication integrity

被引:1
|
作者
Mihailovic, Dragutin T. [1 ]
Kostic, Vladimir R. [2 ]
Balaz, Igor [2 ]
Kapor, Darko [2 ]
机构
[1] Univ Novi Sad, Fac Agr, Novi Sad 21000, Serbia
[2] Univ Novi Sad, Fac Sci, Novi Sad 21000, Serbia
关键词
Nanotubes; Gap junctions; Pseudospectrum; Stability; MATRIX NEARNESS PROBLEMS; MEMBRANE NANOTUBES; DISTANCE; EXCHANGE;
D O I
10.1016/j.chaos.2016.06.001
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
We explore how the biochemical substance exchange through tunneling nanotubes (TNTs) affects the functional stability of a multicellular system. We focus on two questions: whether TNTs can either stabilize or destabilize intercellular communication governed by gap junctions (GJs)? and how to determine the threshold at which influence of TNTs destabilize GJ-mediated communication? The goal of this article is to introduce the way in which the concept of pseudospectra can be used to provide the answers. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:174 / 179
页数:6
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