Identification of a multi-reassortant G12P[9] rotavirus with novel VP1, VP2, VP3 and NSP2 genotypes in a child with acute gastroenteritis

被引：12

作者：

De Grazia, Simona ^{[1
]}

Giammanco, Giovanni M. ^{[1
]}

Doro, Renata ^{[2
]}

Bonura, Floriana ^{[1
]}

Marton, Szilvia ^{[2
]}

Cascio, Antonio ^{[3
]}

Martella, Vito ^{[4
]}

Banyai, Krisztian ^{[2
]}

机构：

[1] Univ Palermo, Dept Hlth Promot Sci & Mother & Child Care G DAle, I-90127 Palermo, Italy

[2] Hungarian Acad Sci, Vet Med Res Inst, Agr Res Ctr, Budapest, Hungary

[3] Univ Messina, Dept Human Pathol, Messina, Italy

[4] Univ Aldo Moro Bari, Dept Vet Med, Valenzano, Italy

来源：

INFECTION GENETICS AND EVOLUTION | 2015年 / 35卷

基金：

匈牙利科学研究基金会;

关键词：

Human rotavirus; G12P[9; Full genome sequencing; Genotyping; Interspecies transmission; Reassortment; POLYMERASE-CHAIN-REACTION; GROUP-A ROTAVIRUSES; GENOMIC ANALYSIS; PORCINE; STRAINS; SPREAD;

D O I：

10.1016/j.meegid.2015.07.023

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The G12 rotavirus genotype is globally emerging to cause severe gastroenteritis in children. Common G12 rotaviruses have either a Wa-like or DS-1-like genome constellation, while some G12 strains may have unusual genome composition. In this study, we determined the full-genome sequence of a G12P[9] strain (ME848/12) detected in a child hospitalized with acute gastroenteritis in Italy in 2012. Strain ME848/12 showed a complex genetic constellation (G12-P[91417-R12-C12-M11-A12-N12-T7-E6-H2), likely derived from multiple reassortment events, with the VP1, VP2, VP3 and NSP2 genes being established as novel genotypes R12, C12, M11 and N12, respectively. Gathering sequence data on human and animal rotaviruses is important to trace the complex evolutionary history of atypical RVAs. (C) 2015 Elsevier BM. All rights reserved.

引用

页码：34 / 37

页数：4

共 47 条

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